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Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.
TLDR
Overexpression of VPS34p resulted in an increase in PI 3-kinase activity, and this activity was specifically precipitated with antisera to Vps34p. Expand
Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast
TLDR
Analysis of a temperature-conditional allele of VPS15 and of the defects in cellular PtdIns(3)P levels in various vps15 and vsp34 mutant strains has led to additional insights into the importance of Ptdins 3- kinase activity in intracellular localization, as well as the roles of Vps15p and Vps34p in vacuolar protein sorting. Expand
Engineering of protein secretion in yeast: strategies and impact on protein production
TLDR
This mini-review focuses on recent strategies and their advantages for systematic engineering of yeast strains for effective protein secretion. Expand
AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain.
TLDR
The plant cDNA does not rescue a yeast vps34 deletion mutant, but a chimeric gene in which the coding sequence for the C-terminal third of VPS34 is replaced by the corresponding sequence from the plant gene does rescue the yeast mutant. Expand
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development
TLDR
In D. discoideum, different PI kinases regulate distinct cellular processes, including cell growth, development, and protein trafficking, with all of the encoded proteins sharing a common highly conserved catalytic core domain. Expand
Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis.
TLDR
Critical roles of a novel druggable target, polypeptide N-acetylgalactosaminyl transferase 6 (GALNT6), which is upregulated in a great majority of breast cancers and encodes a glycosyltransferase responsible for initiating mucin-type O-glycosylation are reported. Expand
Genome Sequence of the White Koji Mold Aspergillus kawachii IFO 4308, Used for Brewing the Japanese Distilled Spirit Shochu
TLDR
The genome sequence of Aspergillus kawachii IFO 4308 was determined and annotated and may provide insight into the properties of this fungus that make it superior for use in shochu production, leading to the further development of A. kawACHii for industrial applications. Expand
Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.
TLDR
A role for Apm1 associated with the Golgi/endosome function, thereby affecting various cellular processes, including secretion, cytokinesis, vacuole fusion, and cell integrity is suggested and it is suggested that calcineurin is involved in these events. Expand
Isolation and characterization of an invertase and its repressor genes from Schizosaccharomyces pombe.
TLDR
The results showed that glucose repression of inv1(+) gene is dependent on scr1 (+) gene, and S. pombe cAMP signalling pathway may not be essential for glucose repression of inv2(+), and an S.pombe gene (scr1(+)) that encodes a homolog of the Aspergillus nidulans CREA which is required for glucose repression the glyconeogenic pathway is identified. Expand
Role of Septins in the Orientation of Forespore Membrane Extension during Sporulation in Fission Yeast
TLDR
During yeast sporulation, a forespore membrane (FSM) initiates at each spindle-pole body and extends to form the spore envelope, and septin mutations result in disoriented FSM extension. Expand
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