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PICALM gene

Known as: CLATHRIN ASSEMBLY LYMPHOID-MYELOID LEUKEMIA GENE, LAP, DROSOPHILA, HOMOLOG OF, phosphatidylinositol binding clathrin assembly protein 
This gene plays a role in receptor mediated endocytosis.
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer's disease… Expand
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Highly Cited
2015
Highly Cited
2015
PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that reduced expression of PICALM in AD… Expand
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Highly Cited
2012
Highly Cited
2012
Background: Recent GWA studies have demonstrated an association between the endocytic clathrin adaptor PICALM and Alzheimer… Expand
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Highly Cited
2011
Highly Cited
2011
OBJECTIVES To identify novel loci for late-onset Alzheimer disease (LOAD) in Caribbean Hispanic individuals and to replicate the… Expand
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Highly Cited
2010
Highly Cited
2010
OBJECTIVES To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD… Expand
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Highly Cited
2010
Highly Cited
2010
CONTEXT Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset… Expand
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease… Expand
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Highly Cited
2010
Highly Cited
2010
In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on… Expand
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Highly Cited
2009
Highly Cited
2009
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the… Expand
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Highly Cited
2009
Highly Cited
2009
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the… Expand
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