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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
A caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD) have now been identified in the cytoplasmic fraction of mouse lymphoma cells and seems to function as a chaperone for CAD during its synthesis, remaining complexed with CAD to inhibit its DNase activity. Expand
Apoptosis by Death Factor
  • S. Nagata
  • Biology, Medicine
  • Cell
  • 7 February 1997
This work was supported in part by Grants-in-Aid from the Ministry of Education, Science, and Culture of Japan and by a Research Grant from the Princess Takamatsu Cancer Research Fund, and performed in part through Special Coordination Funds of the Science and Technology Agency of the Japanese Government. Expand
The Fas death factor
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereasExpand
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
The Ipr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus. Expand
Identification of a factor that links apoptotic cells to phagocytes
Results indicate that milk fat globule-EGF-factor 8 secreted from activated macrophages binds to apoptotic cells, and brings them to phagocytes for engulfment. Expand
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
Northern hybridization revealed that Fas ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T cell-mediated cytotoxicity and in several nonlymphoid tissues, such as testis. Expand
Lethal effect of the anti-Fas antibody in mice
The findings suggest that the Fas antigen is important in programmed cell death in the liver, and may be involved in fulminant hepatitis in some cases. Expand
Calcium-dependent phospholipid scrambling by TMEM16F
It is shown that TMEM16F (transmembrane protein 16F) is an essential component for the Ca2+-dependent exposure of PtdSer on the cell surface, which results from a defect in phospholipid scrambling activity and is found to carry a mutation at a splice-acceptor site of the gene encoding TMEM 16F, causing the premature termination of the protein. Expand
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
The results indicate that activation of CAD downstream of the caspase cascade is responsible for internucleosomal DNA degradation during apoptosis, and that ICAD works as an inhibitor of this process. Expand
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed. Expand