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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
A large genome-wide association study of 2,032 individuals from France with Alzheimer's disease and 5,328 controls identified other risk loci, which support roles of CLU and CR1 in the clearance of β amyloid (Aβ) peptide, the principal constituent of amyloids plaques, which are one of the major brain lesions of individuals with Alzheimer’s disease.
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease
Meta-analyses of all data provided compelling evidence that ABCA7 and the MS4A gene cluster are new Alzheimer's disease susceptibility loci and independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance.
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
A large genome-wide association meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants
Vascular risk factors, incidence of MCI, and rates of progression to dementia
In this population, among those who progressed to dementia, 60% progressed to AD and 33% to VaD and there was a nonsignificant trend for stroke as a risk factor of progression of MCI to dementia.
Late-life depression, mild cognitive impairment, and dementia: possible continuum?
- F. Panza, V. Frisardi, V. Solfrizzi
- Psychology, MedicineThe American journal of geriatric psychiatry…
- 1 February 2010
Clinical and epidemiologic research has focused on the identification of risk factors that may be modified in predementia syndromes, at a preclinical and early clinical stage of dementing disorders,…
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks. We calculated AD…