Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice
It is reported that tingible body macrophages in the germinal centers of the spleen and lymph nodes strongly express MFG-E8, a protein that binds to apoptotic cells by recognizing phosphatidylserine and that enhances the engulfment of apoptosis cells by macrophage.
Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication.
The majority of cases of RA-LPD show similar clinicopathological characteristics irrespective of MTX medication, except for spontaneous regression of LPD after withdrawal of MTZ, and a shorter interval between the diagnosis of RA and LPD in MTX-L PD than in non-MTX- LPD.
Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease.
The findings in this report indicate that the generation of IL-6 by B cells in germinal centers of hyperplastic lymph nodes of Castleman's disease may be the key element responsible for the variety of clinical symptoms in this disease.
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease.
Hemoglobin, albumin, and total cholesterol levels, high-density lipoprotein cholesterol values, and body mass index all increased significantly, and fatigue diminished, in patients with MCD.
Immunohistochemical detection of WT1 protein in a variety of cancer cells
Western blot analysis showed that WT1 protein was predominantly expressed in the cy toplasm of the tumor cells in two cases of lung adenocarcinoma, supporting the intracytoplasmic staining for WT1 using immunohistochemistry.
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Cancer risk after renal transplantation in Japan
The findings showed the excess risk of malignancies in Japan with renal transplants, especially in male patients, similar to that observed in Western countries, though the types ofmalignancy were different.
Pyothorax-associated lymphoma: a review of 106 cases.
- S. Nakatsuka, Masayuki Yao, Y. Hoshida, Satoru Yamamoto, K. Iuchi, K. Aozasa
- MedicineJournal of Clinical Oncology
- 15 October 2002
This study established the distinct nature of PAL as a disease entity, a non-Hodgkin's lymphoma of exclusively B-cell phenotype in the pleural cavity of patients with long-standing history of pyothorax, and is strongly associated with EBV infection.
Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator.
Data suggest that the weak androgenic effect of HF may be amplified by increasing the amount of GSN after androgen ablation treatment, and blockage of the interaction between AR and GSN could become a potential therapeutic target for the treatment of prostate cancer.
Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression.
- Y. Oka, A. Tsuboi, H. Sugiyama
- Medicine, BiologyProceedings of the National Academy of Sciences…
- 21 September 2004
It was demonstrated that WT1 vaccination could induce WT1-specific cytotoxic T lymphocytes and result in cancer regression without damage to normal tissues.