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Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice
Apoptotic cells expose phosphatidylserine and are swiftly engulfed by macrophages. Milk fat globule epidermal growth factor (EGF) factor 8 (MFG-E8) is a protein that binds to apoptotic cells byExpand
Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication.
OBJECTIVE Individuals with rheumatoid arthritis (RA) with or without methotrexate (MTX) medication occasionally develop lymphoproliferative disorders (MTX-LPD and non-MTX-LPD, respectively). TheExpand
Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease.
Castleman's disease is a syndrome consisting of giant lymph node hyperplasia with plasma cell infiltration, fever, anemia, hypergammaglobulinemia, and an increase in the plasma level of acute phaseExpand
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Type I interferons (IFNs) are critical for antiviral responses. Here we generated a knockin mouse in which green fluorescence protein (GFP) was expressed under the control of the Ifna6 promoter.Expand
Immunohistochemical detection of WT1 protein in a variety of cancer cells
WT1 was first identified as a tumor suppressor involved in the development of Wilms’ tumor. Recently, oncogenic properties of WT1 have been demonstrated in various hematological malignancies andExpand
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease.
Multicentric Castleman disease (MCD) is an atypical lymphoproliferative disorder characterized by systemic lymphadenopathy and constitutional inflammatory symptoms. Dysregulated overproduction ofExpand
Cancer risk after renal transplantation in Japan
Excess of cancer in patients receiving renal transplantation is well‐known in Western countries, but information in Japan remains limited. Our study examined whether excess risk is found in patientsExpand
Pyothorax-associated lymphoma: a review of 106 cases.
PURPOSE Pyothorax-associated lymphoma (PAL) is a non-Hodgkin's lymphoma developing in the pleural cavity after a long-standing history of pyothorax. Full details of PAL are provided here. PATIENTSExpand
Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression.
The Wilms' tumor gene WT1 is overexpressed in leukemias and various types of solid tumors, and the WT1 protein was demonstrated to be an attractive target antigen for immunotherapy against theseExpand
Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator.
The partial agonist effect of antiandrogens has been well documented, and such effect is amplified by derived mutant androgen receptors (ARs) in prostate cancer cells. Here we report theExpand