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PI3 protein, human

Known as: protease inhibitor 3, skin-derived (SKALP), human, WFDC14 protein, human, elafin protein, human 
Elafin (117 aa, ~12 kDa) is encoded by the human PI3 gene. This protein plays a role in the inhibition of neutrophil and pancreatic elastase… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (2)

ElafinSerine Proteinase Inhibitors
Extracellular MatrixGenes, RegulatorPI3 genePI3 wt Allele

Papers overview

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Highly Cited
2007
Highly Cited
2007
Angiopoietin chemotactic activities on neutrophils are regulated by PI‐3K activation
Angiopoietins (Ang1 and Ang2) modulate blood vessel integrity during the angiogenic process through the activation of tyrosine… 
Highly Cited
2005
Highly Cited
2005
Host defense effector molecules in mucosal secretions.
Highly Cited
2004
Highly Cited
2004
A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells
Mouse skin tumorigenicity studies indicate that benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE) contributes to carcinogenesis as… 
2004
2004
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
5-Methylchrysene has been found to be a complete carcinogen in laboratory animals. However, the tumor promotion effects of… 
Highly Cited
2003
Highly Cited
2003
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather…
Effects of the PI-3 kinase inhibitor LY294002 (LY) have been examined in relation to responses of human leukemia cells to histone… 
Highly Cited
2001
Highly Cited
2001
Human Alveolar Macrophages Express Elafin and Secretory Leukocyte Protease Inhibitor
Abstract Elafin and secretory leukocyte protease inhibitor (SLPI) are two structurally related serine protease inhibitors present… 
1996
1996
Accelerated Evolution in Inhibitor Domains of Porcine Elafin Family Members (*)
Through the analysis of the porcine gene encoding the elastase inhibitor elafin, we demonstrated that there are at least three… 
Highly Cited
1996
Highly Cited
1996
Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung.
Secretory leukocyte proteinase inhibitor (SLPI) and alpha1-proteinase inhibitor (alpha1(PI)) cannot fully explain the total… 
Highly Cited
1993
Highly Cited
1993
Secretion of mucus proteinase inhibitor and elafin by Clara cell and type II pneumocyte cell lines.
The regulation of proteinases secreted by neutrophils is very important for the prevention of tissue injury. We recently… 
1992
1992
Identification of distinct populations of PI-3 kinase activity following T-cell activation.
Activation of mature CD4+ T lymphocytes by antigen-presenting cells involves engagement of the CD3/T-cell antigen receptor… 
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