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PI3 protein, human

Known as: protease inhibitor 3, skin-derived (SKALP), human, WFDC14 protein, human, elafin protein, human 
Elafin (117 aa, ~12 kDa) is encoded by the human PI3 gene. This protein plays a role in the inhibition of neutrophil and pancreatic elastase… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (2)

ElafinSerine Proteinase Inhibitors
Extracellular MatrixGenes, RegulatorPI3 genePI3 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Expression of natural antimicrobials by human placenta and fetal membranes.
Highly Cited
2007
Highly Cited
2007
Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons.
Review
2004
Review
2004
Human cancer, PTEN and the PI-3 kinase pathway.
Highly Cited
2004
Highly Cited
2004
The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway
BackgroundGab1 is a docking protein that recruits phosphatidylinositol-3 kinase (PI-3 kinase) and other effector proteins in… 
Highly Cited
2004
Highly Cited
2004
The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3…
Phosphoinositide-3 kinase (PI-3 kinase) and its downstream signaling molecules PDK-1 and Akt were analyzed in SK-N-SH and SK-N-BE… 
Highly Cited
2002
Highly Cited
2002
Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization.
The family of p21-activated kinases (PAKs) have been implicated in the rearrangement of actin cytoskeleton by acting downstream… 
Highly Cited
2002
Highly Cited
2002
Overexpression of the Serine Elastase Inhibitor Elafin Protects Transgenic Mice From Hypoxic Pulmonary Hypertension
Background—Increased serine elastase activity has been implicated in the vascular remodeling associated with chronic hypoxia… 
Highly Cited
2000
Highly Cited
2000
A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling
ABSTRACT The Gab1 protein is tyrosine phosphorylated in response to various growth factors and serves as a docking protein that… 
Highly Cited
1996
Highly Cited
1996
Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin
Previously we have shown that PDGF receptor mutants that do not bind PI- 3 kinase internalize after ligand binding, but fail to… 
Highly Cited
1994
Highly Cited
1994
Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.
Human platelet-derived growth factor receptors (PDGFRs) expressed in human Hep G2 cells internalized and concentrated in a… 
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