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Elafin

Known as: Protease Inhibitor 3, Skin derived, Skin Derived Antileukoproteinase, Peptidase Inhibitor 3, Skin derived 
A secretory proteinase inhibitory protein that was initially purified from human SKIN. It is found in a variety mucosal secretions and is present at… 
National Institutes of Health

Related topics

Related topics

12 relations
In BloodPI3 genePI3 wt AlleleProcess of secretion

Narrower (1)

PI3 protein, human

Broader (1)

Protease Inhibitors

Papers overview

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Highly Cited
2011
Highly Cited
2011
Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions.
Review
2007
Review
2007
Innate immune defences in the human uterus during pregnancy.
2005
2005
Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin
Abstract A number of serine, cysteine, metallo- and acid proteases were evaluated for their ability to proteolytically cleave the… 
Highly Cited
2004
Highly Cited
2004
Adenoviral Gene Delivery of Elafin and Secretory Leukocyte Protease Inhibitor Attenuates NF-κB-Dependent Inflammatory Responses of Human Endothelial Cells and Macrophages to Atherogenic Stimuli1
Atherosclerosis is a chronic inflammatory disease affecting arterial vessels. Strategies to reduce the inflammatory responses of… 
Highly Cited
2002
Highly Cited
2002
Overexpression of the Serine Elastase Inhibitor Elafin Protects Transgenic Mice From Hypoxic Pulmonary Hypertension
Background—Increased serine elastase activity has been implicated in the vascular remodeling associated with chronic hypoxia… 
Highly Cited
2002
Highly Cited
2002
Characterization of Reconstructed Skin Models
The aim of the present study was to evaluate tissue architecture and lipid composition of commercially available reconstructed… 
Highly Cited
2002
Highly Cited
2002
Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata.
Highly Cited
2001
Highly Cited
2001
Human Alveolar Macrophages Express Elafin and Secretory Leukocyte Protease Inhibitor
Abstract Elafin and secretory leukocyte protease inhibitor (SLPI) are two structurally related serine protease inhibitors present… 
Highly Cited
2000
Highly Cited
2000
Characterization and comparison of reconstructed skin models: morphological and immunohistochemical evaluation.
Reconstructed human skin equivalents are currently being investigated as in vitro models for the prediction of human skin… 
Highly Cited
1993
Highly Cited
1993
Immunohistochemical localization of SKALP/elafin in psoriatic epidermis.
Recently we have reported the purification and biochemical characterization of a new, inducible elastase inhibitor [skin-derived… 
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