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Elafin

Known as: Protease Inhibitor 3, Skin derived, Skin Derived Antileukoproteinase, Peptidase Inhibitor 3, Skin derived 
A secretory proteinase inhibitory protein that was initially purified from human SKIN. It is found in a variety mucosal secretions and is present at… 
National Institutes of Health

Related topics

Related topics

12 relations
In BloodPI3 genePI3 wt AlleleProcess of secretion

Narrower (1)

PI3 protein, human

Broader (1)

Protease Inhibitors

Papers overview

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2012
2012
Anti-HIV-1 Activity of Elafin Depends on Its Nuclear Localization and Altered Innate Immune Activation in Female Genital Epithelial Cells
Elafin (E) and its precursor trappin-2 (Tr) are alarm antiproteases with antimicrobial and immunomodulatory activities. Tr and E… 
2009
2009
The protease inhibitor, elafin, induces p53‐dependent apoptosis in human melanoma cells
Expression of the protease inhibitor elafin is deregulated in several human cancers. However, functions of the protein in cancer… 
2007
2007
Characterization of human pre-elafin mutants: full antipeptidase activity is essential to preserve lung tissue integrity in experimental emphysema.
Pre-elafin is a tight-binding inhibitor of neutrophil elastase and myeloblastin; two enzymes thought to contribute to tissue… 
2005
2005
Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin
Abstract A number of serine, cysteine, metallo- and acid proteases were evaluated for their ability to proteolytically cleave the… 
2005
2005
Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3
Neutrophil proteinase‐mediated lung tissue destruction is prevented by inhibitors, including elafin and its precursor, trappin… 
2002
2002
Anti-Inflammatory Effect of Pre-Elafin in Lipopolysaccharide-Induced Acute Lung Inflammation
Abstract The aim of the present study was to evaluate the antiinflammatory activity of preelafin, an elastasespecific inhibitor… 
Highly Cited
2001
Highly Cited
2001
Human Alveolar Macrophages Express Elafin and Secretory Leukocyte Protease Inhibitor
Abstract Elafin and secretory leukocyte protease inhibitor (SLPI) are two structurally related serine protease inhibitors present… 
2000
2000
Gene Transfer of the Serine Elastase Inhibitor Elafin Protects Against Vein Graft Degeneration
Background—Leukocyte infiltration and serine elastase activity lead to smooth muscle cell proliferation in association with… 
Highly Cited
1996
Highly Cited
1996
Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung.
Secretory leukocyte proteinase inhibitor (SLPI) and alpha1-proteinase inhibitor (alpha1(PI)) cannot fully explain the total… 
Highly Cited
1993
Highly Cited
1993
Kinetics of the inhibition of human leukocyte elastase by elafin, a 6-kilodalton elastase-specific inhibitor from human skin.
We have investigated the kinetics of inhibition of human leukocyte elastase by elafin, a small protein originally isolated from… 
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