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- Publications
- Influence
Cellular and molecular pathobiology of pulmonary arterial hypertension.
- M. Humbert, N. Morrell, +8 authors M. Rabinovitch
- Medicine
- Journal of the American College of Cardiology
- 16 June 2004
Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction, remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary vascular… Expand
Molecular pathogenesis of pulmonary arterial hypertension.
- M. Rabinovitch
- Medicine
- The Journal of clinical investigation
- 2008
Recent investigations have suggested that it might be possible to reverse the pathology of pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal despite current… Expand
Subversion of Cellular Autophagosomal Machinery by RNA Viruses
- W. Jackson, T. Giddings, +4 authors K. Kirkegaard
- Biology, Medicine
- PLoS biology
- 26 April 2005
Infection of human cells with poliovirus induces the proliferation of double-membraned cytoplasmic vesicles whose surfaces are used as the sites of viral RNA replication and whose origin is unknown.… Expand
Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension.
- M. Rabinovitch, C. Guignabert, M. Humbert, M. Nicolls
- Biology, Medicine
- Circulation research
- 20 June 2014
This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie the development of pulmonary arterial hypertension. The… Expand
Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features.
- M. Rabinovitch, W. Gamble, A. Nadas, O. Miettinen, L. Reid
- Medicine
- The American journal of physiology
- 1 June 1979
In 55 Sprague-Dawley rats (mean wt, 277 +/- 6.2 g) exposed to hypobaric hypoxia (air at 380 mmHg), and 23 weight-matched controls kept in room air, pulmonary and systemic artery pressures were… Expand
Interdependent Serotonin Transporter and Receptor Pathways Regulate S100A4/Mts1, a Gene Associated With Pulmonary Vascular Disease
- A. Lawrie, E. Spiekerkoetter, +7 authors M. Rabinovitch
- Biology, Medicine
- Circulation research
- 5 August 2005
Heightened expression of the S100 calcium–binding protein, S100A4/Mts1, is observed in pulmonary vascular disease. Loss of serotonin (5-hydroxytryptamine [5-HT]) receptors or of the serotonin… Expand
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
- E. Spiekerkoetter, X. Tian, +18 authors M. Rabinovitch
- Medicine, Biology
- The Journal of clinical investigation
- 1 August 2013
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high-throughput luciferase… Expand
Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation.
- G. Hansmann, Roger A. Wagner, +7 authors M. Rabinovitch
- Medicine
- Circulation
- 2007
BACKGROUND
Patients with pulmonary arterial hypertension (PAH) have reduced expression of apolipoprotein E (apoE) and peroxisome proliferator-activated receptor-gamma in lung tissues, and deficiency… Expand
Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease.
- K. Cowan, P. Jones, M. Rabinovitch
- Biology, Medicine
- The Journal of clinical investigation
- 2000
Increased expression of the glycoprotein tenascin-C (TN) is associated with progression of clinical and experimental pulmonary hypertension. In cultured smooth muscle cells (SMCs) TN is induced by… Expand
Pulmonary arterial remodeling induced by a Th2 immune response
- E. Daley, Claire Emson, +9 authors G. Grunig
- Biology
- 11 February 2008
Daley et al. 2008. J. Exp. Med. doi:10.1084/jem.20071008[OpenUrl][1][Abstract/FREE Full Text][2]
[1]:… Expand