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Glypican-3–Deficient Mice Exhibit Developmental Overgrowth and Some of the Abnormalities Typical of Simpson-Golabi-Behmel Syndrome
TLDR
It is reported that GPC3-deficient mice exhibit several of the clinical features observed in SGBS patients, including developmental overgrowth, perinatal death, cystic and dyplastic kidneys, and abnormal lung development.
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Keratinocyte growth factor and its receptor are involved in regulating early lung branching.
TLDR
The results suggest that the KGF/KGFR system has a critical role in early lung organogenesis and is implicated to be a regulator of these tissue interactions.
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Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion.
TLDR
It is concluded that in the current model TH is protective versus IR lung injury and mechanisms of protection include preservation of lung mechanics, attenuation of pulmonary inflammation, and reduction of free radical mediated injury.
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Mechanical force-induced signal transduction in lung cells.
TLDR
New insights are led into how cells sense mechanical stimulation, transmit signals intra- and intercellularly, and regulate gene expression at the transcriptional and posttranscriptional levels at the cellular and molecular levels.
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Lung inflammation as a therapeutic target in cystic fibrosis.
TLDR
The mechanisms responsible for inflammation in the CF lung are examined, potential therapeutic strategies targeting inflammation are discussed, and potential therapeutic strategy targeting inflammation is discussed.
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Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat.
TLDR
Examining the role of neutrophils in the rat model of BPD by inhibiting neutrophil influx using SB265610, a selective CXC chemokine receptor-2 antagonist suggests that exposure of the neonatal lung to moderate hyperoxia may enhance postnatal lung growth, provided postnatal pulmonary inflammation is suppressed.
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Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation
TLDR
It is reported here that the expression of another member of the Ets family transcription factors ESE-1, as well as E SE-3, is upregulated by the inflammatory cytokines interleukin-1β and tumor necrosis factor-α in bronchial epithelial cell lines.
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Increased Po2 alters the bioelectric properties of fetal distal lung epithelium.
TLDR
The results suggest that the physiological increase in alveolar Po2 at birth is, at least in part, responsible for distal lung's permanent switch from Cl secretion to Na absorption at birth.
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Antisense oligonucleotides for PDGF-B and its receptor inhibit mechanical strain-induced fetal lung cell growth.
TLDR
Results suggest that physical forces such as fetal breathing movements regulate fetal lung cell growth by controlling PDGF-B andPDGF-beta-R gene expression.
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Changes in Structure, Mechanics, and Insulin-Like Growth Factor-Related Gene Expression in the Lungs of Newborn Rats Exposed to Air or 60% Oxygen
TLDR
Data are consistent with a direct effect of O2 on growth factor and growth factor receptor expression in causing dysplastic lung cell growth in chronic neonatal lung injury.
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