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PHLPP2 gene

Known as: KIAA0931, PH DOMAIN AND LEUCINE-RICH REPEAT PROTEIN PHOSPHATASE-LIKE, PHLPP-LIKE 
This gene is involved in the regulation of apoptosis.
National Institutes of Health

Related topics

Related topics

6 relations
DephosphorylationHydrolysisPHLPP2 protein, humanProtein dephosphorylation

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS…
Supplemental Digital Content is available in the text. Objective: A decrease in nitric oxide, leading to vascular smooth muscle… 
2019
2019
miR-493 Promotes Prostate Cancer Cells Proliferation by Targeting PHLPP2 and Activating Akt Signaling Pathway.
Background: MicroRNA-493 (miR-493) was upregulated in prostate cancer (PCa). This study was designed to investigate the mechanism… 
2018
2018
miR-214-Dependent Increase of PHLPP2 Levels Mediates the Impairment of Insulin-Stimulated Akt Activation in Mouse Aortic Endothelial Cells Exposed to Methylglyoxal
Evidence has been provided linking microRNAs (miRNAs) and diabetic complications, by the regulation of molecular pathways… 
2016
2016
Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100)
Although the precursor protein of NFκB2 (p100) is thought to act as a tumor suppressor in mammalian cells, the molecular… 
2016
2016
Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL.
Serine/threonine kinase Akt is a downstream effector of insulin receptor/PI3K pathway that is involved in many processes… 
2015
2015
miR‐372 Regulates Glioma Cell Proliferation and Invasion by Directly Targeting PHLPP2
MicroRNAs are known to be involved in carcinogenesis and tumor progression in glioma. Recently, microRNA‐372 (miR‐372) has been… 
2014
2014
Biochemical Characterization of the Phosphatase Domain of the Tumor Suppressor PH Domain Leucine-Rich Repeat Protein Phosphatase
PH domain leucine-rich repeat protein phosphatase (PHLPP) directly dephosphorylates and inactivates Akt and protein kinase C and… 
2014
2014
Assembly of the FKBP51–PHLPP2–AKT signaling complex in cerebral ischemia/reperfusion injury in rats
2013
2013
Pharmacological Inhibition of Pleckstrin Homology Domain Leucine-Rich Repeat Protein Phosphatase Is Neuroprotective: Differential Effects on Astrocytes
Pleckstrin homology domain and leucine-rich repeat protein phosphatase 1 (PHLPP1) inhibits protein kinase B (AKT) survival… 
2010
2010
Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL
J. Neurochem. (2010) 113, 477–488. 
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