• Publications
  • Influence
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition.
TLDR
This review highlights the need to understand more fully the rationale behind the rapid decline in response to certain types of head injuries in children with severe brain injuries. Expand
Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway*
TLDR
Gender stratification is supported in the evaluation of mechanisms and treatment of CNS disease, particularly those where glutathione may play a role in detoxification, such as Parkinson's disease, traumatic brain injury, and conditions producing cerebral ischemia, and may apply to non-CNS diseases as well. Expand
Clinical trials in head injury.
TLDR
This workshop proved to be very informative and yielded many insights into previous and future TBI trials, and it is hoped that these lessons will enhance the planning and design of future efforts in this important field of research. Expand
Cytochrome c/cardiolipin relations in mitochondria: a kiss of death.
TLDR
This review is focused on redox mechanisms and essential structural features of cyt c's conversion into a CL-specific peroxidase that represent an interesting and maybe still unique example of a functionally significant ligand change in hemoproteins. Expand
Caspase‐3 Mediated Neuronal Death After Traumatic Brain Injury in Rats
TLDR
It is demonstrated that caspase‐3 activation contributes to brain tissue loss and downstream biochemical events that execute programmed cell death after traumatic brain injury and Caspase inhibition may prove efficacious in the treatment of certain types of brain injury where programmed cellDeath occurs. Expand
Treatment of traumatic brain injury with moderate hypothermia.
TLDR
Treatment with moderate hypothermia for 24 hours in patients with severe traumatic brain injury and coma scores of 5 to 7 on admission hastened neurologic recovery and may have improved the outcome. Expand
Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children.
TLDR
Serum NSE, S100B, or myelin basic protein are increased in the majority of children with acute nTBI and iTBI, including well-appearing children with iTBI in whom the diagnosis might otherwise have been missed. Expand
Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system
TLDR
This review provides evidence that the therapeutic index of drugs is narrowed during hypothermia, and indicates that intensivists must be aware of these alterations in order to maximize the therapeutic efficacy of this modality. Expand
Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury.
TLDR
Axonal injury was the most prominent feature during the initial 2 weeks following blast exposure, although degeneration of other neuronal processes was also present, and represents a recommended outcome measure in future studies of blast TBI. Expand
Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.
TLDR
It is demonstrated that IL-6 is increased after TBI in children to levels similar to those reported in adults and is the first to show thatIL-10 is increased in CSF of humans afterTBI. Expand
...
1
2
3
4
5
...