Assembly of the FKBP51–PHLPP2–AKT signaling complex in cerebral ischemia/reperfusion injury in rats

@article{Wei2014AssemblyOT,
  title={Assembly of the FKBP51–PHLPP2–AKT signaling complex in cerebral ischemia/reperfusion injury in rats},
  author={Xiu-E Wei and Feng-Yu Zhang and Kundong Wang and Qing-Xiu Zhang and Liang-Qun Rong},
  journal={Brain Research},
  year={2014},
  volume={1566},
  pages={60-68}
}
The imbalance of cell pro-death and pro-survival signaling pathways determines the neuronal fate during cerebral ischemia/reperfusion (I/R) injury. However, the biological mechanisms regulating the balance between activation of the pro-death or the pro-survival signaling pathways remain unclear. In this study, a rat model of I/R injury was established using four-vessel occlusion followed by different times of reperfusion. I/R injury did not affect the level of FK506 binding protein 51 (FKBP51… CONTINUE READING