PHLPP1 wt Allele

Known as: PLEKHE1, SCOP, PHLPP 
Human PHLPP1 wild-type allele is located in the vicinity of 18q21.32 and is approximately 265 kb in length. This allele, which encodes PH domain… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Long non-coding RNAs (lncRNAs) play regulatory roles in cancers. LncRNA PTENP1 is a pseudogene of the tumor suppressor gene PTEN… (More)
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Highly Cited
2013
Highly Cited
2013
AKT signaling is constitutively activated in various cancers, due in large part to loss-of-function in the PTEN and PHLPP… (More)
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2011
2011
PHLPP belongs to a novel family of protein phosphatases that serve as negative regulators of Akt. There are two isoforms, PHLPP1… (More)
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Highly Cited
2009
Highly Cited
2009
Akt is a central regulator of cell growth. Its activity can be negatively regulated by the phosphatase PHLPP that specifically… (More)
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Highly Cited
2009
Highly Cited
2009
PHLPP (PH domain leucine-rich repeats protein phosphatase) represents a family of novel Ser/Thr protein phosphatases. Two highly… (More)
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Highly Cited
2008
Highly Cited
2008
The life cycle of protein kinase C (PKC) is controlled by multiple phosphorylation and dephosphorylation steps. The maturation of… (More)
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Highly Cited
2007
Highly Cited
2007
Akt/protein kinase B controls cell growth, proliferation, and survival. We recently discovered a novel phosphatase PHLPP, for PH… (More)
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Highly Cited
2007
Highly Cited
2007
Because activation of ERK1/2 MAP kinase (MAPK) is critical for hippocampus-dependent memory, there is considerable interest in… (More)
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Highly Cited
2005
Highly Cited
2005
Akt/protein kinase B critically regulates the balance between cell survival and apoptosis. Phosphorylation of Akt at two key… (More)
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1995
1995
In the present study, the effects of scopolamine (SCOP) were determined upon the performance of rats in the five-choice serial… (More)
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