Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

PHLPP1 wt Allele

Known as: PLEKHE1, SCOP, PHLPP 
Human PHLPP1 wild-type allele is located in the vicinity of 18q21.32 and is approximately 265 kb in length. This allele, which encodes PH domain… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Long non-coding RNAs (lncRNAs) play regulatory roles in cancers. LncRNA PTENP1 is a pseudogene of the tumor suppressor gene PTEN… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2013
Highly Cited
2013
AKT signaling is constitutively activated in various cancers, due in large part to loss-of-function in the PTEN and PHLPP… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Akt is a central regulator of cell growth. Its activity can be negatively regulated by the phosphatase PHLPP that specifically… Expand
  • figure 1
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
PHLPP (PH domain leucine-rich repeats protein phosphatase) represents a family of novel Ser/Thr protein phosphatases. Two highly… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2008
Highly Cited
2008
The life cycle of protein kinase C (PKC) is controlled by multiple phosphorylation and dephosphorylation steps. The maturation of… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2008
Review
2008
Metastasis is responsible for 90% of cancer patient deaths. More information is needed about the molecular basis for its… Expand
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Akt/protein kinase B controls cell growth, proliferation, and survival. We recently discovered a novel phosphatase PHLPP, for PH… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Because activation of ERK1/2 MAP kinase (MAPK) is critical for hippocampus-dependent memory, there is considerable interest in… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Akt/protein kinase B critically regulates the balance between cell survival and apoptosis. Phosphorylation of Akt at two key… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
The effects of physostigmine and scopolamine were evaluated on working memory of rats in object recognition and radial-maze tests… Expand
  • table 1
  • table 2
  • figure 2
  • figure 1
  • figure 3
Is this relevant?