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PHLPP1 gene

Known as: KIAA0606, SUPRACHIASMATIC NUCLEUS CIRCADIAN OSCILLATORY PROTEIN, SCOP 
This gene plays a role in the dephosphorylation of proteins.
National Institutes of Health

Related topics

Related topics

8 relations
DephosphorylationHydrolysisPHLPP1 protein, humanProtein dephosphorylation

Broader (1)

Genes

Narrower (1)

PHLPP1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Silencing of TRIM11 suppresses the tumorigenicity of chordoma cells through improving the activity of PHLPP1/AKT
Tripartite motif-containing protein 11 (TRIM11), a member of RING family of E3 ubiquitin ligases, is identified as an oncogene in… 
2018
2018
Tumor necrosis factor‐alpha upregulated PHLPP1 through activating nuclear factor‐kappa B during myocardial ischemia/reperfusion
2017
2017
Postnatal calpain inhibition elicits cerebellar cell death and motor dysfunction
Calpain-1 deletion elicits neurodevelopmental disorders, such as ataxia. However, the function of calpain in postnatal… 
2016
2016
Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression.
2015
2015
MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression.
2015
2015
Low expression of PHLPP1 in sacral chordoma and its association with poor prognosis.
Sacral chordoma is a rare spine tumor with a high recurrence rate even after optimal therapy. Previous studies have demonstrated… 
2014
2014
Biochemical Characterization of the Phosphatase Domain of the Tumor Suppressor PH Domain Leucine-Rich Repeat Protein Phosphatase
PH domain leucine-rich repeat protein phosphatase (PHLPP) directly dephosphorylates and inactivates Akt and protein kinase C and… 
2013
2013
Pharmacological Inhibition of Pleckstrin Homology Domain Leucine-Rich Repeat Protein Phosphatase Is Neuroprotective: Differential Effects on Astrocytes
Pleckstrin homology domain and leucine-rich repeat protein phosphatase 1 (PHLPP1) inhibits protein kinase B (AKT) survival… 
2013
2013
NFκB1 (p50) suppresses SOD2 expression by inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axis
This study reports a novel function of p50 in its regulation of SOD2 transcription via an NFκB-independent pathway. p50-regulated… 
2010
2010
PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus
J. Neurochem. (2010) 115, 941–955. 
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