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PF 5901

Known as: PF-5901 
 

Topic mentions per year

Topic mentions per year

1992-1996
024619921996

Papers overview

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1996
1996
Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors.
Prostaglandins and leukotrienes differentially regulate the production of interleukin-1 (IL-1) in monocytes. It was, therefore… (More)
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1995
1995
Role of lipoxygenase metabolites in platelet-activating factor- and antigen-induced bronchial hyperresponsiveness and eosinophil infiltration.
The effect of a novel leuktriene B4 receptor antagonist N-[5[[8-(1-hydroxy-2- phenyl)ethyl]dibenzofuran-2yl]5-hydroxypentanoyl… (More)
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1994
1994
Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits.
1. The effect of a single intratracheal dose (10 mg) of PF 5901 (2-[3(1-hydroxyhexyl) phenoxymethyl] quinoline hydrochloride, a… (More)
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1993
1993
Prostaglandins inhibit inflammatory mediator release from rat mast cells.
BACKGROUND Mast cells have been implicated in the pathogenesis of gastric ulceration. It is possible that prostaglandins exert… (More)
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1992
1992
Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis.
The ability of nonsteroidal anti-inflammatory drugs to exacerbate experimental colitis, and the possible contributions of the… (More)
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1992
1992
Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on PAF-induced airway responses in neonatally immunized rabbits.
1. Aerosol administration of platelet activating factor (PAF) (80 micrograms ml-1 for 60 min) to neonatally immunized rabbits… (More)
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1992
1992
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy
The role of leukotrienes in the pathogenesis of acute gastric ulceration induced by nonsteroidal antiinflammatory drugs was… (More)
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1992
1992
PF-5901 inhibits gastrointestinal platelet-activating factor synthesis in vivo.
PF-5901, a novel anti-inflammatory compound, has previously been shown to inhibit the synthesis of platelet-activating factor… (More)
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1992
1992
Platelet-activating factor synthesis by peritoneal mast cells and its inhibition by two quinoline-based compounds.
1. Peritoneal mast cells from rat were co-incubated in vitro in a platelet aggregometer cuvette with washed rabbit platelets. In… (More)
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1992
1992
Neutrophil infiltration into the ischaemic/reperfused rabbit isolated myocardium: effect of PF-5901 and cycloheximide.
The Langendorff-perfused rabbit heart preparation has been used to study the interaction of isolated rabbit neutrophils with… (More)
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