Effects of 5−Lipoxygenase Inhibitors on Interleukin Production by Human Synovial Tissues in Organ Culture: Comparison with Interleukin−1−synthesis Inhibitors *

@article{Rainsford1996EffectsO5,
  title={Effects of 5−Lipoxygenase Inhibitors on Interleukin Production by Human Synovial Tissues in Organ Culture: Comparison with Interleukin−1−synthesis Inhibitors *},
  author={K. D. Rainsford and C. Ying and Fred Smith},
  journal={Journal of Pharmacy and Pharmacology},
  year={1996},
  volume={48}
}
Prostaglandins and leukotrienes differentially regulate the production of interleukin−1 (IL−1) in monocytes. It was, therefore, decided to investigate the effects of some 5−lipoxygenase inhibitors compared with standard IL−1−synthesis inhibitors on the production of IL−1 by human synovial tissue explants in organ culture. Human synovial (from hip/knee arthroplasty) or porcine tibio‐tarsal joint synovial explants were incubated in organ culture in Dulbecco's Modified Eagle's Medium + 5% foetal… Expand
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