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Global effect of PEG-IFN-α and ribavirin on gene expression in PBMC in vitro
TLDR
It is indicated that IFN treatment causes upregulation of genes associated with the stress response, apoptosis, and signaling, and an equal number of genes are downregulated, including those associated with protein synthesis, specific cytokines and chemokines and other biosynthetic functions. Expand
Global effect of PEG-IFN-alpha and ribavirin on gene expression in PBMC in vitro.
TLDR
It is indicated that IFN treatment causes upregulation of genes associated with the stress response, apoptosis, and signaling, and an equal number of genes are downregulated, including those associated with protein synthesis, specific cytokines and chemokines and other biosynthetic functions. Expand
Oncostatin M stimulates monocyte chemoattractant protein-1- and interleukin-1-induced matrix metalloproteinase-1 production by human synovial fibroblasts in vitro.
TLDR
Results suggest that OSM has potentially important functions in the modulation of chemokine and metalloproteinase production by synovial cells of the joint. Expand
Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro.
TLDR
While PGE2 alone has limited effects on synovial cell production of IL-8 and GMCSF, its effects are significant in context ofIL-1 alpha stimulation; endogenous P GE2 may alter cytokines secreted by mesenchymally derived cells. Expand
Effects of Meloxicam, Compared with other NSAIDs, on Cartilage Proteoglycan Metabolism, Synovial Prostaglandin E2, and Production of Interleukins 1, 6 and 8, in Human and Porcine Explants in Organ
TLDR
Meloxicam, a new NSAID, was compared with standard NSAIDs for its effect on proteoglycan synthesis and degradation in human and porcine cartilage explants, as well as the production of prostaglandin E2 (PGE2) and interleukins 1 and 6 by human synovial tissue explants in‐vitro. Expand
Effects of 5−Lipoxygenase Inhibitors on Interleukin Production by Human Synovial Tissues in Organ Culture: Comparison with Interleukin−1−synthesis Inhibitors *
TLDR
The results suggest that some 5−lipoxygenase inhibitors may be usefully employed in regulating production of those interleukins involved in joint cartilage destruction, and suggest that this drug exerts its effects by promoting production of IL−1 inhibitors. Expand
Selective effects of some 5-lipoxygenase inhibitors on synovial interleukin-1 (IL-1) production compared with IL-1 synthesis inhibitors
TLDR
MK886, L-656,224, PF-5901, and tepoxalin all inhibited IL-1 production in concentrations up to 10 μM, whereas other 5-LO inhibitors (ICI-211,965, zileuton), as well asIL-1 synthesis inhibitors (IX-207,887, tenidap), were inactive. Expand