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Resolution of in flammation: state of the art, definitions and terms
A consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti‐inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today.
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
It is shown that the CDK inhibitor R-roscovitine markedly enhances resolution of established neutrophil-dependent inflammation in carrageenan-elicited acute pleurisy, bleomycin-induced lung injury, and passively induced arthritis in mice.
Apoptotic cell clearance: basic biology and therapeutic potential
The current understanding of the complex process of apoptotic cell clearance in physiology and pathology is reviewed, and how this knowledge could be harnessed for new therapeutic strategies are discussed.
Inflammatory Resolution: new opportunities for drug discovery
This review offers an alternative approach to the development of novel therapeutics based on the endogenous mediators and mechanisms that switch off acute inflammation and bring about its resolution.
The role of the purinergic P2X7 receptor in inflammation
The P2X7 receptor is increasingly recognised as an important cell surface regulator of several key inflammatory molecules including IL-1β, IL-18, TNF-α and IL-6 and antagonists of this receptor are likely to have therapeutic potential as novel anti-inflammatory therapies.
NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosis in Vitro*
Light is shed on the biochemical and molecular mechanisms regulating human granulocyte apoptosis and, in particular, on the transcription factor NF-κB, which plays a crucial role in regulating the physiological cell death pathway in granulocytes.
Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease
- S. Fox, A. Leitch, R. Duffin, C. Haslett, A. Rossi
- Biology, MedicineJournal of Innate Immunity
- 11 February 2010
This review focuses on the physiological regulation of neutrophil apoptosis with respect to the innate immune system and highlights recent advances in mechanistic understanding of apoptotic pathways and their therapeutic manipulation in appropriate and excessive innate immune responses.
Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function.
- Sarah L. Farnworth, N. Henderson, T. Sethi
- Biology, MedicineAmerican Journal of Pathology
- 1 February 2008
It is demonstrated that galectin-3 is a key molecule in the host defense against pneumococcal infection andTherapeutic strategies designed to augment galectIn-3 activity may both enhance inflammatory cell function and have direct bacteriostatic activity, improving clinical outcomes after severe pneumococal infection.
The anti-inflammatory effects and the inhibition of neutrophil responsiveness by Barleria lupulina and Clinacanthus nutans extracts.
Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.
It is shown that bronchoalveolar lavage fluid obtained from asthmatic patients contains significantly elevated levels of MIF as compared to nonatopic normal volunteers and that the physiological stimuli C5a and IL-5 also cause significant MIF release.