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Effects of Meloxicam, Compared with other NSAIDs, on Cartilage Proteoglycan Metabolism, Synovial Prostaglandin E2, and Production of Interleukins 1, 6 and 8, in Human and Porcine Explants in Organ
Meloxicam, a new NSAID, was compared with standard NSAIDs for its effect on proteoglycan synthesis and degradation in human and porcine cartilage explants, as well as the production of prostaglandin E2 (PGE2) and interleukins 1 and 6 by human synovial tissue explants in‐vitro. Expand
Effects of 5−Lipoxygenase Inhibitors on Interleukin Production by Human Synovial Tissues in Organ Culture: Comparison with Interleukin−1−synthesis Inhibitors *
The results suggest that some 5−lipoxygenase inhibitors may be usefully employed in regulating production of those interleukins involved in joint cartilage destruction, and suggest that this drug exerts its effects by promoting production of IL−1 inhibitors. Expand
Selective effects of some 5-lipoxygenase inhibitors on synovial interleukin-1 (IL-1) production compared with IL-1 synthesis inhibitors
MK886, L-656,224, PF-5901, and tepoxalin all inhibited IL-1 production in concentrations up to 10 μM, whereas other 5-LO inhibitors (ICI-211,965, zileuton), as well asIL-1 synthesis inhibitors (IX-207,887, tenidap), were inactive. Expand
Mechanisms of skin rashes from fenbufen
Inflammatory reactions from fenbufen may therefore, arise from production of its metabolites which yield IL-1 upon exposure to UV radiation. Expand