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PARP2 gene

Known as: ADP-RIBOSYLTRANSFERASE 2, Poly (ADP-Ribose) Polymerase 2 Gene, ADP-RIBOSYLTRANSFERASE-LIKE 2 
This gene is involved in base excision repair of DNA.
National Institutes of Health

Related topics

Related topics

6 relations
Base Excision RepairDNA RepairPARP1 genePARP2 protein, human

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PARP2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Progress and outlook in studying the substrate specificities of PARPs and related enzymes
Despite decades of research on ADP‐ribosyltransferases (ARTs) from the poly(ADP‐ribose) polymerase (PARP) family, one key aspect… 
2018
2018
microRNA‐383 suppresses the PI3K‐AKT‐MTOR signaling pathway to inhibit development of cervical cancer via down‐regulating PARP2
This study aims to evaluate the effect of the regulatory relationship between microRNA‐383 (miR‐383) and PARP2 in the cell… 
Highly Cited
2016
Highly Cited
2016
Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly…
We discovered and developed a novel series of tetrahydropyridophthlazinones as poly(ADP-ribose) polymerase (PARP) 1 and 2… 
2016
2016
Rare Variation in TET2 Is Associated with Clinically Relevant Prostate Carcinoma in African Americans
Background: Common variants have been associated with prostate cancer risk. Unfortunately, few are reproducibly linked to… 
Review
2014
Review
2014
Poly(ADP-ribose) polymerases in double-strand break repair: focus on PARP1, PARP2 and PARP3.
2014
2014
Development and validation of high-throughput screening assays for poly(ADP-ribose) polymerase-2 inhibitors.
2013
2013
Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks
Summary ADP-ribosylation of proteins at DNA lesions by ADP-ribosyltransferases (ARTs) is an early response to DNA damage. The… 
2011
2011
The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest.
Highly Cited
2004
Highly Cited
2004
Regulators of G‐Protein Signaling 3 and 4 (RGS3, RGS4) Are Associated with Glioma Cell Motility
Diffuse brain invasion is a major reason for poor prognosis of glioma patients. The molecular mechanisms underlying infiltration… 
Highly Cited
2001
Highly Cited
2001
Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.
Multicellular organisms must have means of preserving their genomic integrity or face catastrophic consequences such as… 
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