Skip to search formSkip to main contentSkip to account menu

PARP1 gene

Known as: PARP1, ADPRT1, ADP-RIBOSYLTRANSFERASE 
This gene is involved in cellular repair and apoptosis.
National Institutes of Health

Related topics

Related topics

16 relations
ADP Ribose TransferasesBase Excision RepairDNA RepairPARP1 protein, human

Narrower (1)

PARP1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53-Mutated Multiple Myeloma Cells
DNA cross-linking agents are frequently used in the treatment of multiple myeloma–generating lesions, which activate checkpoint… 
2012
2012
Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition.
Review
2012
Review
2012
Towards a structural understanding of PARP1 activation and related signalling ADP-ribosyl-transferases.
2011
2011
Discovery and Biological Activity of 6BrCaQ as an Inhibitor of the Hsp90 Protein Folding Machinery
Heat shock protein 90 (Hsp90) is a significant target in the development of rational cancer therapy, due to its role at the… 
Highly Cited
2009
Highly Cited
2009
Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis.
Tanshinone IIA, a diterpene quinone extracted from the traditional herbal medicine, Salvia miltiorrhiza Bunge, has been reported… 
2009
2009
The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells.
Ceramides are central molecules in sphingolipid metabolism. They are involved in the regulation of cancer-cell growth… 
Highly Cited
2001
Highly Cited
2001
Cytotoxic and apoptotic effects of cobalt and chromium ions on J774 macrophages – Implication of caspase-3 in the apoptotic pathway
The aim of this study was to evaluate the cytotoxic and apoptotic effects of cobalt and chromium ions on macrophages in vitro… 
Highly Cited
1999
Highly Cited
1999
Selective Loss of Poly(ADP-ribose) and the 85-kDa Fragment of Poly(ADP-ribose) Polymerase in Nucleoli during Alkylation-induced Apoptosis of HeLa Cells*
Alkylation treatment of HeLa cells results in the rapid induction of apoptosis as revealed by DNA laddering and cleavage of poly… 
Highly Cited
1995
Highly Cited
1995
Different basal NAD levels determine opposite effects of poly(ADP-ribosyl)polymerase inhibitors on H2O2-induced apoptosis.
We have recently described that poly(ADP-ribosyl)-polymerase (PARP) inhibitors rescue U937 cells from apoptosis induced by 1 mM… 
1993
1993
Molecular cloning of PARP (proline/arginine‐rich protein) from human cartilage and subsequent demonstration that PARP is a fragment of the NH2‐terminal domain of the collagen α2(XI) chain
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)