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PARP1 wt Allele

Known as: ADPRT 1, ADPRT1, pADPRT-1 
Human PARP1 wild-type allele is located within 1q41-q42 and is approximately 47 kb in length. This allele, which encodes poly [ADP-ribose] polymerase… 
National Institutes of Health

Related topics

Related topics

14 relations
1q42ADP Ribose TransferasesAIF PathwayBase Excision Repair

Broader (1)

PARP1 gene

Papers overview

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2013
2013
The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining.
2012
2012
Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition.
Highly Cited
2009
Highly Cited
2009
PARP-1 Val762Ala polymorphism, CagA+H. pylori infection and risk for gastric cancer in Han Chinese population
Introduction PARP-1 plays important role in the BER (base excision repair) and maintenance of genomic integrity. Previous study… 
2005
2005
Cyclosporine A and its non‐immunosuppressive derivative NIM811 induce apoptosis of malignant melanoma cells in in vitro and in vivo studies
Advanced melanoma is a highly malignant tumor with an increasing incidence that has a poor prognosis due to resistance to common… 
2005
2005
Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors.
We previously demonstrated that intravenous or intra-cerebral administration of poly (ADP-ribose) polymerase-1 (PARP-1… 
2003
2003
Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage.
Highly Cited
2000
Highly Cited
2000
Characterization of sPARP-1
Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme that catalyzes the synthesis of poly(ADP-ribose) (pADPr… 
Highly Cited
2000
Highly Cited
2000
Depletion of intracellular NAD(+) and ATP levels during ricin-induced apoptosis through the specific ribosomal inactivation results in the cytolysis of U937 cells.
Our previous studies demonstrated that ricin induces the apoptotic death of U937 cells as evidenced by DNA fragmentation, nuclear… 
Highly Cited
1998
Highly Cited
1998
Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP).
Highly Cited
1995
Highly Cited
1995
trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon
Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalyzed by poly(ADP-ribose) polymerase (PARP; EC… 
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