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Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells.
TLDR
The results of this study suggest that there are at least two forms of the nuclear Ah receptor complex in MCF-7 cells; the major transcriptionally active form binds [3H]TCDD and flavones 1 or 2 inhibit nuclear uptake of this receptor complex.
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Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1.
Dimethylformamide (DMF) is an industrial solvent with hepatotoxic properties. The toxicity of DMF has been associated with its metabolism to S-(N-methylcarbamoyl)glutathione (SMG). The major urinary…
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Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists.
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Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite.
TLDR
It is highly likely that N-methylformamide is oxidized and conjugated to form S-methylcarbamoyl)glutathione which is metabolized further to N-acetyl-S-(N-methyl CarbamoyL) cysteine, which could be hydrolyzed to give the parent thiol and the observed metabolic end products, methylamine and carbon dioxide.
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α‐Methylacyl‐CoA racemase – an ‘obscure’ metabolic enzyme takes centre stage
TLDR
New research in both the metabolism of branched‐chain lipids and their role in cancer is considered, with particular emphasis on the crucial role played by AMACR.
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Poly(ADP-ribose)polymerase inhibition - where now?
TLDR
Five questions remain if PARP-1 inhibitors are to realise their potential in treating human diseases and the answers to these questions will determine the future of disease therapy through inhibition of PARP.
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Differences between rodents and humans in the metabolic toxification of N,N-dimethylformamide.
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Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP).
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Characterisation of recombinant human fatty aldehyde dehydrogenase: Implications for Sjögren-Larsson syndrome
TLDR
Results place FALDH in a central role in the fatty alcohol/acid interconversion cycle, and provide a direct link between enzyme inactivation and disease pathology caused by accumulation of alcohols.
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The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes.
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