Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks.

@article{Couto2013NonhomologousEP,
  title={Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks.},
  author={C. Anne-Marie Couto and D Hsu and Regina Teo and Alina R Rakhimova and Styliana Lempidaki and Catherine J. Pears and Nicholas D Lakin},
  journal={Journal of cell science},
  year={2013},
  volume={126 Pt 15},
  pages={3452-61}
}
ADP-ribosylation of proteins at DNA lesions by ADP-ribosyltransferases (ARTs) is an early response to DNA damage. The best defined role of ADP-ribosylation in the DNA damage response is in repair of single strand breaks (SSBs). Recently, we initiated a study of how ADP-ribosylation regulates DNA repair in Dictyostelium and found that two ARTs (Adprt1b and Adprt2) are required for tolerance of cells to SSBs, and a third ART (Adprt1a) promotes nonhomologous end-joining (NHEJ). Here we report that… CONTINUE READING

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PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.

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