PARP2 protein, human

Known as: PARP-2 protein, human, PARP2, NAD(+) ADP-Ribosyltransferase 2 
Poly [ADP-ribose] polymerase 2 (583 aa, ~66 kDa) is encoded by the human PARP2 gene. This protein is involved in the initiation of DNA repair.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Small-molecule inhibitors of PARP are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA… (More)
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Review
2012
Review
2012
Poly(ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose groups to target proteins and thereby affect various… (More)
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Review
2012
Review
2012
Poly(ADP-ribose) polymerase (PARP) catalyzed poly(ADP-ribosyl)ation is one of the earliest post-translational modification of… (More)
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Review
2010
Review
2010
Poly(ADP-ribosyl)ation is a ubiquitous protein modification found in mammalian cells that modulates many cellular responses… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE To evaluate the preclinical pharmacokinetics and antitumor efficacy of a novel orally bioavailable poly(ADP-ribose… (More)
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2007
2007
Genotoxic stress activates nuclear poly(ADP-ribose) (PAR) metabolism leading to PAR synthesis catalyzed by DNA damage activated… (More)
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2006
2006
Thyroid transcription factor 1 (TTF-1/Nkx-2.1) plays a critical role in lung morphogenesis and regulates the expression of lung… (More)
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Highly Cited
2004
Highly Cited
2004
Regulating the topological state of DNA is a vital function of the enzyme DNA topoisomerase I. However, when acting on damaged… (More)
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2004
2004
Werner syndrome (WS) is a genetic premature aging disorder in which patients appear much older than their chronological age. The… (More)
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2002
2002
Caspase-8 is the prototypic initiator of the death domain receptor pathway of apoptosis. Here, we report that caspase-8 not only… (More)
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