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PARP2 protein, human

Known as: PARP-2 protein, human, PARP2, NAD(+) ADP-Ribosyltransferase 2 
Poly [ADP-ribose] polymerase 2 (583 aa, ~66 kDa) is encoded by the human PARP2 gene. This protein is involved in the initiation of DNA repair.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
BACKGROUND Poly(ADP-ribose) polymerase (PARP) is implicated in DNA repair and transcription regulation. Niraparib (MK4827) is an… Expand
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Highly Cited
2012
Highly Cited
2012
Small-molecule inhibitors of PARP are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA… Expand
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Review
2012
Review
2012
Poly(ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose groups to target proteins and thereby affect various… Expand
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Review
2012
Review
2012
Poly(ADP-ribose) polymerase (PARP) catalyzed poly(ADP-ribosyl)ation is one of the earliest post-translational modification of… Expand
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Highly Cited
2011
Highly Cited
2011
SIRT1 is a NAD(+)-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure… Expand
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Highly Cited
2008
Highly Cited
2008
Poly(ADP-ribose) polymerase activation is an immediate cellular response to metabolic-, chemical-, or ionizing radiation-induced… Expand
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Highly Cited
2007
Highly Cited
2007
Purpose: To evaluate the preclinical pharmacokinetics and antitumor efficacy of a novel orally bioavailable poly(ADP-ribose… Expand
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Highly Cited
2007
Highly Cited
2007
Genome integrity is constantly threatened by DNA lesions arising from numerous exogenous and endogenous sources. Survival depends… Expand
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Highly Cited
2005
Highly Cited
2005
The DNA damage-dependent poly(ADP-ribose) polymerases-1 and -2 (PARP-1 and PARP-2) are survival factors that share overlapping… Expand
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Highly Cited
2003
Highly Cited
2003
The DNA damage‐dependent poly(ADP‐ribose) polymerases, PARP‐1 and PARP‐2, homo‐ and heterodimerize and are both involved in the… Expand
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