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PARP2 wt Allele

Known as: ADPRT2, pADPRT-2, ADP-Ribosyltransferase (NAD+; Poly(ADP-Ribose) Polymerase)-Like 2 Gene 
Human PARP2 wild-type allele is located within 14q11.2-q12 and is approximately 14 kb in length. This allele, which encodes poly [ADP-ribose… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The poly(adenosine diphosphate (ADP)-ribose) polymerase (PARP) protein family generates ADP-ribose (ADPr) modifications onto… Expand
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2014
2014
An excessive activation of poly(ADP-ribose) polymerases (PARPs) may trigger a form of neuronal death similar to that occurring in… Expand
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Highly Cited
2011
Highly Cited
2011
SIRT1 is a NAD(+)-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure… Expand
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2011
2011
AIMS Doxorubicin (DOX) is widely used in cytostatic treatments, although it may cause cardiovascular dysfunction as a side effect… Expand
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2009
2009
Poly(ADP-ribose) polymerase-1 (PARP-1) is a base excision repair (BER) protein that binds to DNA single strand breaks (SSBs) and… Expand
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Highly Cited
2007
Highly Cited
2007
Single-strand breaks are the commonest lesions arising in cells, and defects in their repair are implicated in neurodegenerative… Expand
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Highly Cited
2007
Highly Cited
2007
Poly(ADP-ribose) polymerase 3 (PARP-3) is a novel member of the PARP family of enzymes that synthesize poly(ADP-ribose) on… Expand
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2006
2006
We disclose herein our efforts aimed at discovery of selective PARP-1 and PARP-2 inhibitors. We have recently discovered several… Expand
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2005
2005
The severity of acute pancreatitis results from the transmigration and activation of leukocytes within the pancreas and the local… Expand
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Highly Cited
1999
Highly Cited
1999
Posttranscriptional modification of nuclear proteins by poly(ADP-ribosyl)ation in response to DNA strand breaks plays an… Expand
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