Orexin Receptor Antagonists

Known as: Receptor Antagonists, Orexin, Blockers, Orexin Receptor, Orexin Receptor Blockers 
Substances that bind to and inhibit the action of OREXIN RECEPTORS. Drugs in this class have been used as SLEEP AIDS.
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Orexin-A and -B (also known as hypocretin-1 and -2) are neuropeptides produced in the lateral hypothalamus that promote many… (More)
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Highly Cited
2007
Highly Cited
2007
Orexins are hypothalamic peptides that play an important role in maintaining wakefulness in mammals. Permanent deficit in… (More)
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Review
2001
Review
2001
Orexin-A and orexin-B are neuropeptides originally identified as endogenous ligands for two orphan G-protein-coupled receptors… (More)
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Highly Cited
2001
Highly Cited
2001
The hypothalamic orexin (hypocretin) neuropeptides are associated with the regulation of sleep and feeding, and disturbances in… (More)
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Highly Cited
2001
Highly Cited
2001
Intracerebroventricular (i.c.v.) administration of the novel hypothalamic neuropeptide orexin-A stimulates food intake in rats… (More)
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Highly Cited
2001
Highly Cited
2001
The hypothalamic peptide orexin-A and the orexin-1 receptor are localized in areas of the brain and spinal cord associated with… (More)
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Highly Cited
2000
Highly Cited
2000
Orexin-A is a novel neuropeptide initially isolated from hypothalamic extracts but now known to be present in fibres distributed… (More)
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Highly Cited
1999
Highly Cited
1999
The novel hypothalamic peptides orexin-A and orexin-B are known to induce feeding behavior when administered… (More)
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Highly Cited
1999
Highly Cited
1999
Orexins are recently identified neuropeptides, and have been shown to increase food intake when administered… (More)
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Highly Cited
1998
Highly Cited
1998
The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel… (More)
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