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Orexin Receptor Antagonists

Known as: Receptor Antagonists, Orexin, Blockers, Orexin Receptor, Orexin Receptor Blockers 
Substances that bind to and inhibit the action of OREXIN RECEPTORS. Drugs in this class have been used as SLEEP AIDS.
National Institutes of Health

Related topics

Related topics

10 relations

Narrower (3)

DORA-22Dual Orexin Receptor Antagonistssuvorexant
In BloodOrexin Receptor Antagonist [EPC]Orexin Receptor Antagonists [MoA]analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats
2011
2011
Orange-spotted grouper (Epinephelus coioides) orexin: Molecular cloning, tissue expression, ontogeny, daily rhythm and regulation of NPY gene expression
2011
2011
Activation of orexin/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes
2006
2006
Galanin‐Like Peptide Promotes Feeding Behaviour Via Activation of Orexinergic Neurones in the Rat Lateral Hypothalamus
Galanin‐like peptide (GALP) is produced in neurones in the hypothalamic arcuate nucleus and is implicated in the neural control… 
2004
2004
Orexin-A does not stimulate food intake in old rats.
Aging is associated with a progressive decrease in appetite and food intake. Both A and B orexins, expressed in specific neurons… 
2004
2004
Analgesic effect of intrathecal administration of orexin on neuropathic pain in rats.
Orexin-A, a hypothalamic peptide found in the neurons of the lateral hypothalamus, has been shown to modulate pain. We examined… 
2002
2002
Reduction of blood glucose level by orexins in fasting normal and streptozotocin-diabetic mice.
2002
2002
Chronic central infusion of orexin-A increases arterial pressure in rats
Highly Cited
2001
Highly Cited
2001
Hypothalamic orexin-A-immunpositive neurons express Fos in response to central glucopenia
Reports that glucose antimetabolite treatment elicits hyperphagia and hyperglycemia suggest that decreased oxidation of this… 
2001
2001
Effects of cocaine- and amphetamine-regulated transcript peptide, leptin and orexins on hypothalamic serotonin release.
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