Orexin Receptor Antagonist [EPC]

Abstract Background We evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with… Expand

Objective Various stressors induce stress responses through the hypothalamic–pituitary–adrenal and the sympathetic–adrenal… Expand

Background: Filorexant (MK-6096) is an orexin receptor antagonist; here, we evaluate the efficacy of filorexant in the treatment… Expand

Insomnia is characterized by difficulty in falling asleep, difficulty maintaining sleep, or experiencing nonrestorative sleep… Expand

Primary insomnia is mainly treated with drugs acting on benzodiazepine receptors and a few other classes of drugs used for… Expand

Abstract The combination of stable isotope labeling of amino acids in mammals (SILAM) and laser capture microdissection (LCM) for… Expand

Almorexant, a tetrahydroisoquinoline orexin receptor antagonist and first representative of a new class of compounds for the… Expand

Almorexant, a dual orexin receptor antagonist, was investigated for the treatment of insomnia. The following observations… Expand

Insomnia persistently affects the quality and quantity of sleep. Currently approved treatments for insomnia primarily target… Expand