DORA-22

Known as: ((2R,5R)-5-((5-fluoropyridin-2-yl)oxymethyl)-2-methylpiperidin-1-yl)-(5-fluoro-2-pyrimidin-2-ylphenyl)methanone 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2016
01220122016

Papers overview

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2017
2017
Chronic insomnia is defined as a persistent difficulty with sleep initiation maintenance or non-restorative sleep. The… (More)
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2017
2017
Emotionally salient situations usually trigger arousal along with autonomic and neuroendocrine reactions. To determine whether… (More)
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2016
2016
STUDY OBJECTIVES In addition to enhancing sleep onset and maintenance, a desirable insomnia therapeutic agent would preserve… (More)
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2016
2016
Orexin signaling, known to modulate arousal and vigilance, is also involved in nociception as orexin neurons project to regions… (More)
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2014
2014
The ability to awaken from sleep in response to important stimuli is a critical feature of normal sleep, as is maintaining sleep… (More)
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2014
2014
The current standard of care for insomnia includes gamma-aminobutyric acid receptor A (GABAA) activators, which promote sleep as… (More)
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2013
2013
Current treatments for insomnia, such as zolpidem (Ambien) and eszopiclone (Lunesta), are γ-aminobutyric acid type A (GABAA… (More)
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2013
2013
Drugs targeting insomnia ideally promote sleep throughout the night, maintain normal sleep architecture, and are devoid of… (More)
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2013
2013
Dual orexin receptor antagonists (DORAs) induce sleep by blocking orexin 1 and orexin 2 receptor-mediated activities responsible… (More)
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2012
2012
Orexin (hypocretin) neuropeptides promote wakefulness by signaling through two G-protein coupled receptors, Orexin 1 Receptor (OX… (More)
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