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DORA-22

Known as: ((2R,5R)-5-((5-fluoropyridin-2-yl)oxymethyl)-2-methylpiperidin-1-yl)-(5-fluoro-2-pyrimidin-2-ylphenyl)methanone 
 
National Institutes of Health

Papers overview

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2019
2019
Introduction Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study… Expand
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2017
2017
Emotionally salient situations usually trigger arousal along with autonomic and neuroendocrine reactions. To determine whether… Expand
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2017
2017
Chronic insomnia is defined as a persistent difficulty with sleep initiation maintenance or non-restorative sleep. The… Expand
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2016
2016
STUDY OBJECTIVES In addition to enhancing sleep onset and maintenance, a desirable insomnia therapeutic agent would preserve… Expand
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2014
2014
The ability to awaken from sleep in response to important stimuli is a critical feature of normal sleep, as is maintaining sleep… Expand
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2014
2014
BackgroundThe current standard of care for insomnia includes gamma-aminobutyric acid receptor A (GABAA) activators, which promote… Expand
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Highly Cited
2013
Highly Cited
2013
Selective orexin receptor antagonism promotes sleep at doses lower than those that impair attention and memory in contrast to the… Expand
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2013
2013
BackgroundDrugs targeting insomnia ideally promote sleep throughout the night, maintain normal sleep architecture, and are devoid… Expand
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2013
2013
Dual orexin receptor antagonists (DORAs) induce sleep by blocking orexin 1 and orexin 2 receptor-mediated activities responsible… Expand
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Highly Cited
2012
Highly Cited
2012
Orexin (hypocretin) neuropeptides promote wakefulness by signaling through two G-protein coupled receptors, Orexin 1 Receptor (OX… Expand
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