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suvorexant

Known as: [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, [(7R)-4-(5-Chlor-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanon, methanone, ((7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)- 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (4)

AzepinesOrexin Receptor AntagonistsSleep Aids, PharmaceuticalTriazoles

Narrower (2)

BelsomraMK 4305
Orexin Receptor Antagonists [MoA]suvorexant 15 MG Oral Tablet [Belsomra]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: why sleep on this any longer?
In 2017 the US Department of Health and Human Services declared the epidemic of opioid use disorder (OUD) sweeping the nation a… 
Review
2020
Review
2020
Preliminary examination of the orexin system on relapse-related factors in cocaine use disorder
Highly Cited
2018
Highly Cited
2018
Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine
Orexins (‘hypocretins’) are peptides produced by neurons of the hypothalamus that project to structures implicated in reward and… 
Highly Cited
2017
Highly Cited
2017
Preventive Effects of Suvorexant on Delirium: A Randomized Placebo-Controlled Trial.
OBJECTIVE No highly effective pharmacologic interventions to prevent delirium have been identified. We examined whether… 
2017
2017
Postoperative delirium after pharyngolaryngectomy with esophagectomy: a role for ramelteon and suvorexant
BackgroundPostoperative delirium is common after extensive surgery, and is known to be associated with sleeping medications. In… 
Highly Cited
2016
Highly Cited
2016
Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea.
STUDY OBJECTIVES To investigate the respiratory effects of suvorexant, an orexin receptor antagonist for treating insomnia, in… 
Review
2015
Review
2015
Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials
Objective We performed a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials evaluating… 
2015
2015
Effects of the orexin receptor antagonist suvorexant on respiration during sleep in healthy subjects
Suvorexant is an orexin receptor antagonist for treating insomnia. The maximum approved dose in the United States and Japan is 20… 
Review
2014
Review
2014
Suvorexant: First Global Approval
Suvorexant (Belsomra®), a first-in-class, orally active dual orexin-1 receptor and orexin-2 receptor antagonist, has been… 
Highly Cited
2011
Highly Cited
2011
Reaction development and mechanistic study of a ruthenium catalyzed intramolecular asymmetric reductive amination en route to the dual Orexin inhibitor Suvorexant (MK-4305).
The first example of an intramolecular asymmetric reductive amination of a dialkyl ketone with an aliphatic amine has been… 
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