suvorexant

Known as: [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, [(7R)-4-(5-Chlor-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanon, methanone, ((7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)- 
 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
INTRODUCTION The purpose of this guideline is to establish clinical practice recommendations for the pharmacologic treatment of… (More)
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2016
2016
BACKGROUND Suvorexant is an orexin receptor antagonist for treatment of insomnia. We report results from two pivotal phase 3… (More)
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Review
2016
Review
2016
Insomnia, a highly prevalent disorder, can be detrimental to patients' overall health and worsen existing comorbidities. Patients… (More)
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2016
2016
STUDY OBJECTIVES To investigate the respiratory effects of suvorexant, an orexin receptor antagonist for treating insomnia, in… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Suvorexant (MK-4305) is an orexin receptor antagonist shown to be efficacious for insomnia over 3 months. We aimed to… (More)
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Review
2014
Review
2014
Suvorexant (Belsomra®), a first-in-class, orally active dual orexin-1 receptor and orexin-2 receptor antagonist, has been… (More)
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2013
2013
STUDY OBJECTIVES Suvorexant (MK-4305) is an orexin receptor antagonist being developed for the treatment of insomnia. This report… (More)
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Review
2013
Review
2013
Orexin A and orexin B are hypothalamic neuropeptides initially identified as endogenous ligands for two orphan G-protein coupled… (More)
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Highly Cited
2012
Highly Cited
2012
OBJECTIVE To assess the utility of orexin receptor antagonism as a novel approach to treating insomnia. METHODS We evaluated… (More)
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Highly Cited
2011
Highly Cited
2011
Orexins/hypocretins are key neuropeptides responsible for regulating central arousal and reward circuits. Two receptors respond… (More)
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