• Publications
  • Influence
Physiology and pharmacology of melatonin in relation to biological rhythms.
TLDR
This review surveys the current state of knowledge regarding the regulation of melatonin synthesis, receptor expression, and function and addresses the physiological, pathological, and therapeutic aspects ofmelatonin in humans, with an emphasis on biological rhythms. Expand
Designer cathinones--an emerging class of novel recreational drugs.
TLDR
This review surveys the current state of knowledge regarding the pharmacotoxicological properties of synthetic cathinones, the prevalence and pattern of their use, and the negative consequences of using these products including, among others, cardiovascular, psychiatric and neurologic symptoms, dehydration, rhambdomyolysis, renal and liver failure. Expand
Next generation of novel psychoactive substances on the horizon - A complex problem to face.
TLDR
This review presents updated information on the second generation of NPS, introduced as replacements of the already banned substances from this class, focusing on their pharmacological properties and metabolism, routes of administration, and effects in humans. Expand
Spice/K2 drugs--more than innocent substitutes for marijuana.
TLDR
The current state of knowledge regarding the pharmacological properties of synthetic cannabimimetics and the prevalence and pattern of their use are surveyed, including, among others, hallucinations, psychoses with delusions, seizures, cardiovascular symptoms and acute kidney injury. Expand
Methoxetamine--a novel recreational drug with potent hallucinogenic properties.
TLDR
This review surveys the current state of knowledge regarding the metabolism, pharmacology, prevalence and pattern of methoxetamine use, and analytical methods of its detection. Expand
Prodrugs: a challenge for the drug development.
TLDR
The basic functional groups that are amenable to prodrug design are described, and the major applications of the prodrug strategy are highlighted, including the ability to improve oral absorption and aqueous solubility, increase lipophilicity, enhance active transport, as well as achieve site-selective delivery. Expand
An Expanding World of Novel Psychoactive Substances: Opioids
TLDR
An overview of the pharmacological properties, pattern of use, and desired and unwanted effects of the above-listed novel opioids is provided. Expand
Cytotoxic Activity of Pyrovalerone Derivatives, an Emerging Group of Psychostimulant Designer Cathinones
TLDR
Struckly, the two new generation pyrovalerones seem to be the most potent cytotoxic compounds: both induced highly pronounced mitochondrial dysfunction; the latter also demonstrated significant damage to cell membranes. Expand
"Legal highs" - new players in the old drama.
  • J. Zawilska
  • Psychology, Medicine
  • Current drug abuse reviews
  • 31 May 2011
TLDR
This review surveys the current state of knowledge regarding the pharmacological properties of "legal highs" and addresses the negative consequences of using these products. Expand
"Legal Highs"--An Emerging Epidemic of Novel Psychoactive Substances.
  • J. Zawilska
  • Medicine
  • International review of neurobiology
  • 2015
TLDR
There is limited information available on the potential acute toxicity (harms) associated with the use of these substances, however, the number of intoxicated people presenting with emergencies is constantly increasing, providing evidence that negative health and social consequences may indeed seriously affect recreational and chronic users. Expand
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