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Opioids

Known as: opioid product, opiates in any form, opiate agonists 
A class of synthetic chemicals/drugs similar to opiates (opium derivatives) with analgesic properties. Due to binding to opiate receptors, opioids… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
IMPORTANCE Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic… Expand
Review
2016
Review
2016
This guideline provides recommendations for primary care clinicians who are prescribing opioids for chronic pain outside of… Expand
Highly Cited
2016
Highly Cited
2016
The U.S. opioid epidemic is continuing, and drug overdose deaths nearly tripled during 1999-2014. Among 47,055 drug overdose… Expand
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Review
2010
Review
2010
BACKGROUND Long-term opioid therapy for chronic noncancer pain is becoming increasingly common in community practice. Concomitant… Expand
Review
2009
Review
2009
UNLABELLED Use of chronic opioid therapy for chronic noncancer pain has increased substantially. The American Pain Society and… Expand
Review
2008
Review
2008
Medications which bind to opioid receptors are increasingly being prescribed for the treatment of multiple and diverse chronic… Expand
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Highly Cited
1992
Highly Cited
1992
Increased activity of dopamine-containing neurons in the ventral tegmental area is necessary for the reinforcing effects of… Expand
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Review
1983
Review
1983
  • W. Martin
  • Pharmacological reviews
  • 1983
  • Corpus ID: 7599763
The concept of multiple opioid receptors reconciles a large body of clinical and pharmacological data. Recent studies have shown… Expand
Highly Cited
1977
Highly Cited
1977
Opioid peptides were assayed by inhibition of 3H-naloxone and 3H-leu-enkephalin binding in brain homogenates and by depression of… Expand
Highly Cited
1975
Highly Cited
1975
Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H–Tyr–Gly–Gly–Phe–Met–OH and H–Tyr–Gly–Gly–Phe… Expand