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Opioids

Known as: opioid product, opiates in any form, opiate agonists 
A class of synthetic chemicals/drugs similar to opiates (opium derivatives) with analgesic properties. Due to binding to opiate receptors, opioids… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
IMPORTANCE Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic… 
Review
2016
Review
2016
This guideline provides recommendations for primary care clinicians who are prescribing opioids for chronic pain outside of… 
Highly Cited
2016
Highly Cited
2016
The U.S. opioid epidemic is continuing, and drug overdose deaths nearly tripled during 1999-2014. Among 47,055 drug overdose… 
Review
2010
Review
2010
BACKGROUND Long-term opioid therapy for chronic noncancer pain is becoming increasingly common in community practice. Concomitant… 
Review
2008
Review
2008
Medications which bind to opioid receptors are increasingly being prescribed for the treatment of multiple and diverse chronic… 
Review
2002
Review
2002
BACKGROUND Methadone maintenance was the first widely used form of opioid replacement therapy developed to treat heroin… 
Highly Cited
1992
Highly Cited
1992
Increased activity of dopamine-containing neurons in the ventral tegmental area is necessary for the reinforcing effects of… 
Review
1983
Review
1983
  • W. Martin
  • Pharmacological reviews
  • 1983
  • Corpus ID: 7599763
The concept of multiple opioid receptors reconciles a large body of clinical and pharmacological data. Recent studies have shown… 
Highly Cited
1977
Highly Cited
1977
Opioid peptides were assayed by inhibition of 3H-naloxone and 3H-leu-enkephalin binding in brain homogenates and by depression of… 
Highly Cited
1975
Highly Cited
1975
Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H–Tyr–Gly–Gly–Phe–Met–OH and H–Tyr–Gly–Gly–Phe…