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Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats.
TLDR
Oxytocin exerts a central anxiolytic-like effect on both endocrine and behavioral systems and could play a role in moderating behavioral and physiological responses to stress.
Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription
TLDR
It is demonstrated that ultradian hormone stimulation induces cyclic GR-mediated transcriptional regulation, or gene pulsing, both in cultured cells and in animal models, indicating that biologically accurate regulation of gene targets by GR requires an ultradian mode of hormone stimulation.
Oxytocin Attenuates Stress-Induced c-fos mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity
TLDR
Data show that central oxytocin attenuates both the stress-induced neuroendocrine and molecular responses of the HPA axis and that the dorsal hippocampus, LSV, and PVN constitute an oxytocIn-sensitive forebrain stress circuit.
Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation.
TLDR
A potent and long-term effect of neonatal exposure to inflammatory stimuli that can program major changes in the development of both neuroendocrine and immunological regulatory mechanisms is demonstrated.
Corticotropin-Releasing Factor Increases In VitroFiring Rates of Serotonergic Neurons in the Rat Dorsal Raphe Nucleus: Evidence for Activation of a Topographically Organized Mesolimbocortical
TLDR
The electrophysiological properties and the distribution of responsive neurons within the dorsal raphe nucleus are consistent with the hypothesis that endogenous CRF activates a topographically organized mesolimbocortical serotonergic system.
Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination
TLDR
Elderly carers of spouses with dementia have increased activation of the hypothalamic-pituitary-adrenal axis and a poor antibody response to influenza vaccine, and carers may be more vulnerable to infectious disease than the population of a similar age.
Tryptophan metabolism in the central nervous system: medical implications
TLDR
The molecular mechanisms involved in regulating the metabolism of tryptophan are discussed, the medical implications associated with dysregulation of both serotonergic and kynurenine pathways of tryPTophan metabolism are considered and the pathophysiology of conditions such as acquired immunodeficiency syndrome, Huntington's disease and Alzheimer's disease is considered.
Chronic stress in caregivers of dementia patients is associated with reduced lymphocyte sensitivity to glucocorticoids
TLDR
The results indicate that chronic distress is associated with impaired cell-mediated immunity which is, in turn, associated with elevated basal steroid levels and altered steroid immunoregulation at the level of the lymphocyte.
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