Codeine

Known as: Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, morphine 3-methyl ether, N Methylmorphine 
A naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activities. Codeine mimics the actions… (More)

Topic mentions per year

Topic mentions per year

1937-2018
010020019372017

Papers overview

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Highly Cited
2012
Highly Cited
2012
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy… (More)
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Highly Cited
2009
Highly Cited
2009
n engl j med 361;8 nejm.org august 20, 2009 827 ies in normal controls and patients2; the other does not find any antibodies.1 In… (More)
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Highly Cited
2009
Highly Cited
2009
A large number of women receive codeine for obstetric pain while breastfeeding. Following a case of fatal opioid poisoning in a… (More)
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Highly Cited
2007
Highly Cited
2007
Codeine is an analgesic drug acting on μ-opiate receptors predominantly via its metabolite morphine, which is formed almost… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Chronic noncancer pain (CNCP) is a major health problem, for which opioids provide one treatment option. However… (More)
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Highly Cited
2004
Highly Cited
2004
Life-threatening opioid intoxication developed in a patient after he was given small doses of codeine for the treatment of a… (More)
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Highly Cited
2003
Highly Cited
2003
UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in the glucuronidation of a wide array of clinically important drugs and… (More)
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Highly Cited
1991
Highly Cited
1991
The polymorphic cytochrome P-450 DB1 (P-450 IID6) is responsible for the O-demethylation of codeine to morphine by human liver… (More)
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Highly Cited
1987
Highly Cited
1987
The formalin test in mice is a valid and reliable model of nociception and is sensitive for various classes of analgesic drugs… (More)
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Highly Cited
1972
Highly Cited
1972
Labeled morphine, codeine, heroin, or methadone was injected as a bolus into the common carotid artery of the rat, and the rat… (More)
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