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Codeine

Known as: Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, morphine 3-methyl ether, N Methylmorphine 
A naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activities. Codeine mimics the actions… Expand
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (21)

ACC 30Brompton mixtureCodeine / GuaifenesinCodeine / Promethazine
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AMMONIUM CHLORIDE/CHLORPHENIRAMINE/CODEINE/PHENYLEPHRINE/POTASSIAcetaminophen 300 MG / Codeine Phosphate 30 MG Oral TabletAspirin 325 MG / butalbital 50 MG / Caffeine 40 MG / Codeine Phosphate 30 MG Oral Capsule [Ascomp]Codeine Phosphate 2 MG/ML / Guaifenesin 20 MG/ML Oral Solution
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Broader (4)

AlkaloidsAnalgesicsNarcotic AnalgesicsOpiates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy… Expand
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Highly Cited
2012
Highly Cited
2012
More Codeine Fatalities After Tonsillectomy in North American Children
In 2009 we reported the fatal case of a toddler who had received codeine after adenotonsillectomy for obstructive sleep apnea… Expand
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy… Expand
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Is this relevant?
Highly Cited
2009
Highly Cited
2009
Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
A large number of women receive codeine for obstetric pain while breastfeeding. Following a case of fatal opioid poisoning in a… Expand
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Is this relevant?
Highly Cited
2007
Highly Cited
2007
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
Codeine is an analgesic drug acting on μ-opiate receptors predominantly via its metabolite morphine, which is formed almost… Expand
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Is this relevant?
Highly Cited
2006
Highly Cited
2006
Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
In April, 2005, a full-term healthy male infant, delivered vaginally, showed intermittent periods of diffi culty in breastfeeding… Expand
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Highly Cited
2006
Highly Cited
2006
Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects
Background: Chronic noncancer pain (CNCP) is a major health problem, for which opioids provide one treatment option. However… Expand
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Is this relevant?
Highly Cited
2004
Highly Cited
2004
Codeine intoxication associated with ultrarapid CYP2D6 metabolism.
Life-threatening opioid intoxication developed in a patient after he was given small doses of codeine for the treatment of a… Expand
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Highly Cited
1987
Highly Cited
1987
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain
The formalin test in mice is a valid and reliable model of nociception and is sensitive for various classes of analgesic drugs… Expand
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Highly Cited
1975
Highly Cited
1975
The analgesic properties of delta-9-tetrahydrocannabinol and codeine.
The administration of single oral doses of delta-9-tetrahydrocannabinol (THC) to patients with cancer pain demonstrated a mild… Expand
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