FAQ

Codeine

Known as: Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, morphine 3-methyl ether, N Methylmorphine 
A naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activities. Codeine mimics the actions… (More)

Topic mentions per year

Topic mentions per year

1937-2018
010020019372017

Related topics

Related topics

48 relations

Narrower (28)

14-hydroxycodeineACC 30BRON WCaffetin
(More)
Acetaminophen / CodeineCodeine PhosphateCoughingDrug Allergy
(More)

Broader (4)

AnalgesicsAnalgesics, OpioidAntitussive AgentsNarcotic Analgesics

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Codeine
Drug Allergy
Opioids
Morphine
Pain, Postoperative
Analgesics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy… (More)
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Highly Cited
2009
Highly Cited
2009
Codeine, ultrarapid-metabolism genotype, and postoperative death.
n engl j med 361;8 nejm.org august 20, 2009 827 ies in normal controls and patients2; the other does not find any antibodies.1 In… (More)
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Highly Cited
2009
Highly Cited
2009
Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
A large number of women receive codeine for obstetric pain while breastfeeding. Following a case of fatal opioid poisoning in a… (More)
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Highly Cited
2007
Highly Cited
2007
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
Codeine is an analgesic drug acting on μ-opiate receptors predominantly via its metabolite morphine, which is formed almost… (More)
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Highly Cited
2006
Highly Cited
2006
Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects.
BACKGROUND Chronic noncancer pain (CNCP) is a major health problem, for which opioids provide one treatment option. However… (More)
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Highly Cited
2004
Highly Cited
2004
Codeine intoxication associated with ultrarapid CYP2D6 metabolism.
Life-threatening opioid intoxication developed in a patient after he was given small doses of codeine for the treatment of a… (More)
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Highly Cited
2003
Highly Cited
2003
Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2…
UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in the glucuronidation of a wide array of clinically important drugs and… (More)
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Highly Cited
1991
Highly Cited
1991
Impact of environmental and genetic factors on codeine analgesia
The polymorphic cytochrome P-450 DB1 (P-450 IID6) is responsible for the O-demethylation of codeine to morphine by human liver… (More)
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Highly Cited
1987
Highly Cited
1987
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain.
The formalin test in mice is a valid and reliable model of nociception and is sensitive for various classes of analgesic drugs… (More)
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Highly Cited
1972
Highly Cited
1972
Blood-brain barrier: penetration of morphine, codeine, heroin, and methadone after carotid injection.
Labeled morphine, codeine, heroin, or methadone was injected as a bolus into the common carotid artery of the rat, and the rat… (More)
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