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Codeine

Known as: Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, morphine 3-methyl ether, N Methylmorphine 
A naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activities. Codeine mimics the actions… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Objective This update of a 2011 guideline developed by the American Academy of Otolaryngology–Head and Neck Surgery Foundation… Expand
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Review
2018
Review
2018
Importance Over the past 20 years, opioid misuse and opioid addiction have risen to epidemic proportions in the United States… Expand
Review
2018
Review
2018
Background Prescription opioid misuse has doubled over the past 10 years and is now a public health epidemic. Analysis of social… Expand
Review
2014
Review
2014
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy… Expand
Highly Cited
2007
Highly Cited
2007
Codeine is an analgesic drug acting on μ-opiate receptors predominantly via its metabolite morphine, which is formed almost… Expand
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Highly Cited
2006
Highly Cited
2006
In April, 2005, a full-term healthy male infant, delivered vaginally, showed intermittent periods of diffi culty in breastfeeding… Expand
Highly Cited
2004
Highly Cited
2004
Life-threatening opioid intoxication developed in a patient after he was given small doses of codeine for the treatment of a… Expand
Highly Cited
1987
Highly Cited
1987
&NA; The formalin test in mice is a valid and reliable model of nociception and is sensitive for various classes of analgesic… Expand
Highly Cited
1975
Highly Cited
1975
The administration of single oral doses of delta‐9‐tetrahydrocannabinol (THC) to patients with cancer pain demonstrated a mild… Expand
Highly Cited
1972
Highly Cited
1972
Labeled morphine, codeine, heroin, or methadone was injected as a bolus into the common carotid artery of the rat, and the rat… Expand