3H-Codeine binding in the guinea pig lower brain stem.

@article{Chau19823HCodeineBI,
  title={3H-Codeine binding in the guinea pig lower brain stem.},
  author={T. T. Chau and F. Carter and L. Harris},
  journal={Pharmacology},
  year={1982},
  volume={25 1},
  pages={
          12-7
        }
}
Saturable binding of (-)-3H codeine was found in the guinea pig medulla (KD = 5.6 x 10(-7) M, Bmax = 1.4 pmol/mg protein), whereas little stereospecific binding was detected (KD = 4.4 x 10(-5) M). The saturable binding of (-)-3H codeine was slightly enhanced by Na+ and by Mg++ but not by Li++ and Ca++. The enhancement appears to be due to an increase in the number of receptor sites. (-)-3H-Codeine binding was displaced by (-)- and (+)-codeine, morphine, (-)- and (+)-methadone but not by… Expand
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