Opiates

Known as: Opiate, opium derivatives 
Functionally related to the poppy (Papaver somniferum) alkaloid morphine, natural or synthetic Opiates have widespread effects in the central nervous… (More)

Topic mentions per year

Topic mentions per year

1940-2017
020040019402016

Papers overview

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Highly Cited
2003
Highly Cited
2003
BACKGROUND Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone has been… (More)
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Highly Cited
2001
Highly Cited
2001
Morphine is unusual in its failure to promote robust desensitization and endocytosis of the mu opioid receptor (MOR), processes… (More)
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Highly Cited
2000
Highly Cited
2000
Cessation of drug use in chronic opiate abusers produces a severe withdrawal syndrome that is highly aversive, and avoidance of… (More)
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Highly Cited
2000
Highly Cited
2000
Opiate analgesics are widely used in the treatment of severe pain. Because of their importance in therapy, different strategies… (More)
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Highly Cited
1999
Highly Cited
1999
Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental… (More)
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Highly Cited
1997
Highly Cited
1997
Morphine produces analgesia at opiate receptors expressed in nociceptive circuits. mu, delta, and kappa opiate receptor subtypes… (More)
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Highly Cited
1990
Highly Cited
1990
We have compared the time course of the behavioral manifestations of opiate withdrawal to the in vivo activity of locus coeruleus… (More)
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Highly Cited
1986
Highly Cited
1986
The kappa opioid agonists are analgesics that seem to be free of undesired morphine-like effects. Their dysphoric actions… (More)
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Highly Cited
1977
Highly Cited
1977
The distribution of opiate receptors, determined by the autoradiographic localization of stereospecific [3H]diprenorphine binding… (More)
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Highly Cited
1973
Highly Cited
1973
Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig… (More)
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