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Identification of the Binding Site on Cytochrome P450 2B4 for Cytochrome b 5 and Cytochrome P450 Reductase*
A model of cytochrome P450 2B4, which was constructed by homology modeling with the four known crystal structures of the cytochromes P450 (Chang, T.-T., Stiffelman, O. B., Vakser, I. A., Loew, G. H.,Expand
Molecular dynamics simulations of phospholipid bilayers.
Molecular dynamics (MD) simulations at 37 degrees C have been performed on three phospholipid bilayer systems composed of the lipids DLPE, DOPE, and DOPC. The model used included 24 explicit lipidExpand
The hyperphagic effect of 3α-hydroxylated pregnane steroids in male rats
Like benzodiazepines receptor (BDZR) ligands, 3α-hydroxylated, 5α, or 5β pregnane steroids are sedative, anticonvulsant, and anxiolytic. BDZR ligands also modulate the feeding response. Therefore, inExpand
Pharmacological profiles of fentanyl analogs at μ, δ and κ opiate receptors
Abstract Receptor binding assays using [3H]DAGO ([D-Ala2,MePhe4-Gly5]enkephalin (μ), [3H]DPDPE ([D-Pen2,D-Pen5]enkephalin (δ) and [3H]U-69593 (κ) were done in guinea pig whole brain membranes.Expand
Calculated and experimental absolute stereochemistry of the styrene and .beta.-methylstyrene epoxides formed by cytochrome P 450cam
Cytochrome P450 cam oxidizes styrene to styrene oxide and a trace of phenylacetaldehyde; cis-β-methylstyrene to cis-β-methylstyrene oxide, cis-3-phenyl-2-propen-1-ol, and a trace ofExpand
Evidence for central benzodiazepine receptor heterogeneity from behavior tests
To explore behavioral selectivity as a consequence of multiple receptor subtypes, four benzodiazepine receptor ligands, flunitrazepam, CGS 9896, zolpidem, and AHR 11797, were tested at five in vivoExpand
Determinants of the spin state of the resting state of cytochrome P450cam
The origin of the low-spin ground state of the substrate-free ferric resting state of cytochrome P450 cam has been investigated with use of the combined techniques of restricted open-shellExpand