Role of endogenous opioids in neurohypophysial function of man.

  title={Role of endogenous opioids in neurohypophysial function of man.},
  author={M. Miller},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={50 6},
  • M. Miller
  • Published 1980
  • Medicine, Chemistry
  • The Journal of clinical endocrinology and metabolism
  • Studies were carried out in normal human subjects to determine the effect of two narcotic antagonists, oxilorphan and butorphanol, on antidiuretic hormone (ADH) release. Oxilorphan given to eight subjects on ad libitum fluid intake resulted in a transient but significant increase in 24-h free water clearance and a decrease in urine osmolality. These changes were not accompanied by an increase in creatinine or solute excretion, and urinary ADH levels did not rise even though plasma osmolality… CONTINUE READING
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