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Oncogene E1A

Known as: E1A 
Viral Oncogene E1A encodes E1A Protein, a regulator of early viral gene transcription. E1A interacts with diverse cellular proteins to override host… 
National Institutes of Health

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Adenovirus E1A ProteinsNeoplastic Cell TransformationTranscriptional RegulationVirus Physiological Phenomena

Papers overview

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Highly Cited
1995
Highly Cited
1995
Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms.
E1A of human adenovirus type 5 (Ad5) encodes proteins of 289 and 243 residues (289R and 243R) which differ only by the 46 amino… 
Highly Cited
1990
Highly Cited
1990
Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.
Amplification/overexpression of the human neu protooncogene has been frequently found in human primary breast and ovarian cancers… 
Highly Cited
1988
Highly Cited
1988
The 289-amino acid E1A protein of adenovirus binds zinc in a region that is important for trans-activation.
The E1A gene of adenovirus type 5 encodes two major proteins of 289 and 243 amino acid residues, which are identical except that… 
Highly Cited
1987
Highly Cited
1987
Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.
We have investigated the E1A-inducible E3 promoter of adenovirus type 5 with respect to its ability to bind specific nuclear… 
Highly Cited
1987
Highly Cited
1987
Pentapeptide nuclear localization signal in adenovirus E1a
The adenovirus E1a gene products are nuclear proteins important in transcriptional control of viral functions during infection… 
Highly Cited
1985
Highly Cited
1985
Repression of the immunoglobulin heavy chain enhancer by the adenovirus-2 E1A products.
The products of the adenovirus-2 (Ad2) immortalizing oncogene E1A repress the activity of the SV40, polyoma virus and E1A… 
Highly Cited
1984
Highly Cited
1984
Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription
The adenovirus-2 early region 1A (E1A) products repress activation of transcription induced by the simian virus 40, polyoma virus… 
Highly Cited
1983
Highly Cited
1983
Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element
Highly Cited
1983
Highly Cited
1983
E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes
A product of the adenovirus E1A gene is a positive regulator of early viral gene expression. In this report we show that E1A… 
Highly Cited
1981
Highly Cited
1981
The stability of early adenovirus mRNA is controlled by the viral 72 kd DNA-binding protein
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