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Oncogene E1A

Known as: E1A 
Viral Oncogene E1A encodes E1A Protein, a regulator of early viral gene transcription. E1A interacts with diverse cellular proteins to override host… 
National Institutes of Health

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Adenovirus E1A ProteinsNeoplastic Cell TransformationTranscriptional RegulationVirus Physiological Phenomena

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Inhibition of angiogenesis and induction of apoptosis are involved in E1A-mediated bystander effect and tumor suppression.
Adenovirus type 5 E1A has been implicated in mediation of tumor suppression. Preclinical gene therapy studies have additionally… 
1995
1995
The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains
The transforming E1A 12S and E1A 13S proteins of human adenovirus type 5 (Ad5) contain two and three conserved regions… 
1994
1994
Constructing chimeric type 12/type 5 adenovirus E1A genes and using them to identify an oncogenic determinant of adenovirus type 12
The E1A gene of highly oncogenic type 12 adenovirus (Ad12) possesses a segment unique to this serotype and comprising 60 base… 
1992
1992
Induction of AP-1 DNA-binding activity and c-fos mRNA by the adenovirus 243R E1A protein and cyclic AMP requires domains necessary for transformation
The 243R E1A protein can act in synergy with cyclic AMP to induce AP-1 DNA-binding activity and c-fos mRNA in mouse S49 cells. A… 
Highly Cited
1988
Highly Cited
1988
Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin.
The stromelysin (sml) gene encodes a secreted protease which degrades components of the extracellular matrix. Transformation of… 
1987
1987
Growth factor(s) produced during infection with an adenovirus variant stimulates proliferation of nonestablished epithelial cells.
Infection of primary baby rat kidney cells with an adenovirus variant that encodes only the 12S gene of the E1A region… 
1986
1986
Genetic mapping of a major site of phosphorylation in adenovirus type 2 E1A proteins
Adenovirus early region 1A (E1A) encodes two acidic phosphoproteins which are required for transactivation of viral transcription… 
1986
1986
Adenovirus E1a proteins repress expression from polyomavirus early and late promoters
We have examined the effects of the E1a products of adenovirus types 5 and 12 on the expression of polyomavirus early and late… 
1986
1986
The E4 promoter of adenovirus type 2 contains an E1A dependent cis-acting element.
To study how the E1A polypeptides of adenovirus type 2 regulate transcription, we have constructed chimeric plasmids containing… 
1983
1983
Far upstream initiation sites for adenovirus early region 1A transcription are utilized after the onset of viral DNA replication
Adenovirus early region 1A (E1A) is the first transcription unit expressed after infection. It encodes a protein which controls…