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Structure and function of dopamine receptors
Distinct functions of the two isoforms of dopamine D2 receptors
TLDR
It is shown that these receptors have distinct functions in vivo; D2L acts mainly at postsynaptic sites and D2S serves presynaptic autoreceptor functions, uncovering a circuit of signalling interference between dopamine receptors.
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
TLDR
This study shows that D2 receptors have a key role in the dopaminergic control of nervous function, using homologous recombination to generate D2-receptor-deficient mice, which have therapeutic potential as a model for investigating and correcting dysfunctions of the dopamine system.
Cloning and characterization of a Drosophila tyramine receptor.
TLDR
The Drosophila tyramine receptor that is isolated might be an invertebrate equivalent of the mammalian alpha 2 adrenergic receptors and share a putative seven transmembrane domain structure.
Abnormal Synaptic Plasticity in the Striatum of Mice Lacking Dopamine D2 Receptors
TLDR
This study indicates that D2Rs play a key role in mechanisms underlying the direction of long-term changes in synaptic efficacy in the striatum and shows that an imbalance between D2R and NMDA receptor activity induces altered synaptic plasticity at corticostriatal synapses.
Receptor Subtypes Involved in the Presynaptic and Postsynaptic Actions of Dopamine on Striatal Interneurons
TLDR
Immunohistochemical analyses in both wild-type and D1R-/- mice confirmed the expression of D5 receptors in both cholinergic and parvalbumin-positive interneurons of the striatum, and in mice lacking D2 receptors, the DA-dependent inhibition of GABA transmission was lost in both interneuron populations.
Inhibition of Dopamine Release Via Presynaptic D2 Receptors: Time Course and Functional Characteristics In Vivo
TLDR
Dopamine release was evoked in the striatum of anesthetized mice by electrical stimulation of the medial forebrain bundle and was continuously monitored by amperometry using carbon fiber electrodes and autoinhibition eliciting by one burst transiently attenuates further dopamine release elicited by tonic activity.
Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation
TLDR
The GSK3β kinase phosphorylates BMAL1, an event that controls the stability of the protein and the amplitude of circadian oscillation, uncovering a previously unknown mechanism of circadian clock control.
Impaired locomotion and dopamine signaling in retinoid receptor mutant mice.
In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor beta and retinoid X receptors beta and gamma resulted in locomotor defects related to dysfunction of the
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