O(6)-Methylguanine-DNA Methyltransferase

Known as: Methylated-DNA--Protein-Cysteine Methyltransferase, MGMT, O(6)-MeG-DNA Methyltransferase 
An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1944-2017
010020030019442016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Glioblastoma is common among elderly patients, a group in which comorbidities and a poor prognosis raise important considerations… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
Is this relevant?
Highly Cited
2013
Highly Cited
2013
We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Mitochondrial DNA (mtDNA) has been reported to contain 5-methylcytosine (5mC) at CpG dinucleotides, as in the nuclear genome, but… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
PURPOSE Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at codon 132 have been found in 12% of… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Histone methylation and DNA methylation cooperatively regulate chromatin structure and gene activity. How these two systems… (More)
  • figure 2
Is this relevant?
Highly Cited
2008
Highly Cited
2008
PURPOSE Standard therapy for glioblastoma (GBM) is temozolomide (TMZ) administration, initially concurrent with radiotherapy (RT… (More)
  • table 1
  • figure 1
  • table 2
  • figure 3
  • figure 2
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Recently, a small population of cancer stem cells in adult and pediatric brain tumors has been identified. Some evidence has… (More)
  • table 1
Is this relevant?
Highly Cited
2005
Highly Cited
2005
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
Highly Cited
2000
Highly Cited
2000
BACKGROUND The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the O6 position of guanine. MGMT… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
Is this relevant?