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O(6)-Methylguanine-DNA Methyltransferase

Known as: Methylated-DNA--Protein-Cysteine Methyltransferase, MGMT, O(6)-MeG-DNA Methyltransferase 
An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing… 
National Institutes of Health

Related topics

Related topics

15 relations
Breast CarcinomaDNA RepairEnzyme GeneIn Blood

Broader (1)

Methyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Speciation of arsenic in body fluids.
Highly Cited
2001
Highly Cited
2001
Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma
Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor… 
Highly Cited
2001
Highly Cited
2001
DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization.
OBJECTIVE The aim of this study was to examine CpG island methylation patterns in ovarian cancer and determine whether epigenetic… 
Highly Cited
1995
Highly Cited
1995
Clinicopathologic significance of the K‐ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases
Background. The frequency and clinicopathologic significance of the K‐ras gene point mutation in stomach cancer remain to be… 
Highly Cited
1994
Highly Cited
1994
Saccharide linkage analysis using methylation and other techniques.
Review
1994
Review
1994
Hypermethylation of telomere-like foldbacks at codon 12 of the human c-Ha-ras gene and the trinucleotide repeat of the FMR-1 gene of fragile X.
Runs of G residues on the G-rich strands of 30mers from the region spanning codon 12 of c-Ha-ras appear to be protected against… 
Highly Cited
1981
Highly Cited
1981
IgE-mediated histamine release in rat basophilic leukemia cells: receptor activation, phospholipid methylation, Ca2+ flux, and release of arachidonic acid.
Highly Cited
1980
Highly Cited
1980
Inability of Chinese hamster ovary cells to excise O6-alkylguanine.
The capacity of Chinese hamster ovary cells for excising alkylated bases from their DNA was investigated. Cells were treated with… 
Highly Cited
1975
Highly Cited
1975
Structure of the human erythrocyte blood group P1 glycosphingolipid.
A glycosphingolipid with blood group P1 activity was extracted from an acetone powder of human erythrocyte stroma with chloroform… 
Highly Cited
1964
Highly Cited
1964
METHYLATION OF DEOXYRIBONUCLEIC ACID BY DIAZOMETHANE.
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