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The first relevant cell stage in rat liver carcinogenesis. A quantitative approach.
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STUDIES ON PLASMA MEMBRANES. I. CHEMICAL COMPOSITION AND ENZYME CONTENT OF PLASMA MEMBRANES ISOLATED FROM RAT LIVER.
Abstract Plasma membranes were isolated from rat liver. Electron microscopy showed that the preparations were not contaminated by other identifiable cellular components. Antibodies prepared againstExpand
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Studies on plasma membranes. IV. The ultrastructural localization and content of sialic acid in plasma membranes isolated from rat liver and hepatoma.
Plasma membranes were isolated from rat liver and a transplanted rat hepatoma of the hepatocellular type. After glutaraldehyde fixation the membranes were treated with colloidal iron hydroxide (CIH)Expand
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Studies on plasma membranes. 3. Mg2+-ATPase,(Na+-K+-Mg2+)-ATPase and 5'-nucleotidase activity of plasma membranes isolated from rat liver.
1. 1. Plasma membranes have been isolated from rat liver and the ATPase (EC 3.6.1.4), (Na+-K+)-ATPase and 5′-nucleotidase (EC 3.1.3.5; substrate: AMP) activities of the preparations have beenExpand
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HEXAGONAL ARRAY OF SUBUNITS IN TIGHT JUNCTIONS SEPARATED FROM ISOLATED RAT LIVER PLASMA MEMBRANES
Solubilization of isolated rat liver plasma membranes in 1% deoxycholate and centrifugation yielded a fraction (pellet) that consisted mainly of tight junctions (zonulae occludentes). An hexagonalExpand
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Comparative lipid analysis of purified plasma membranes and shed extracellular membrane vesicles from normal murine thymocytes and leukemic GRSL cells.
The lipid fluidity in purified plasma membranes (PM) of murine leukemic GRSL cells, as measured by fluorescence polarization, is much higher than in PM of normal thymocytes. This was found to be dueExpand
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Kinetics of formation of O6-ethylguanine in, and its removal from liver DNA of rats receiving diethylnitrosamine.
Abstract The ethylation of rat liver DNA by a single dose of diethylnitrosamine and the stability of O6-ethylguanine in vivo were studied. Whereas the dose response relations for 7-ethylguanine,Expand
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Studies on lung tumours. III. Oxidative metabolism of dimethylnitrosamine by rodent and human lung tissue.
The oxidative metabolism of the carcinogen dimethylnitrosamine (DMN) was studied in mouse, rat, hamster and human respiratory tissue. [14C]DMN was purified by Dowex-1-bisulfite column chromatographyExpand
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Increased sialic acid density in surface glycoprotein of transformed and malignant cells--a general phenomenon?
Summary Established lines of malignant (MBVIA) and nonmalignant (MBIII) lymphoblasts, baby hamster kidney cells (BHK21/C13), BHK21/C13 cells transformed by polyoma virus, 3T3 mouse fibroblasts, 3T3Expand
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ELECTRON MICROSCOPIC OBSERVATIONS ON NEGATIVELY STAINED PLASMA MEMBRANES ISOLATED FROM RAT LIVER
The Davson-Daniel l i model of m e m b r a n e structure features a bimolecular leaflet of phospholipids in lamel lar a r rangement , covered on bo th sides by protein (1). This model is in keepingExpand
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