Neuronal Migration Protein Doublecortin

Known as: Lissencephalin-X, Doublecortex, Lis-X 
Neuronal migration protein doublecortin (402 aa, ~45 kDa) is encoded by the human DCX gene. This protein is involved in neuronal migration.
National Institutes of Health

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Cell MovementCytokinesisCytoskeletal GeneCytoskeleton
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis.
Several studies investigated the effect of physical exercise on emotional behaviors in rodents; resulting findings however remain… (More)
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Highly Cited
2007
Highly Cited
2007
The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells.
Doublecortin (DCX) has recently been promulgated as a selective marker of cells committed to the neuronal lineage in both the… (More)
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Highly Cited
2006
Highly Cited
2006
doublecortin-like kinase Functions with doublecortin to Mediate Fiber Tract Decussation and Neuronal Migration
The potential role of doublecortin (Dcx), encoding a microtubule-associated protein, in brain development has remained… (More)
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Highly Cited
2004
Highly Cited
2004
Doublecortin Microtubule Affinity Is Regulated by a Balance of Kinase and Phosphatase Activity at the Leading Edge of Migrating Neurons
Doublecortin (Dcx) is a microtubule-associated protein that is mutated in X-linked lissencephaly (X-LIS), a neuronal migration… (More)
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Review
2003
Review
2003
Doublecortin functions at the extremities of growing neuronal processes.
Type I lissencephaly is a cortical malformation disorder characterized by disorganized cortical layers and gyral abnormalities… (More)
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Highly Cited
2002
Highly Cited
2002
Doublecortin is required in mice for lamination of the hippocampus but not the neocortex.
Doublecortin (DCX) is a microtubule-associated protein that is required for normal neocortical and hippocampal development in… (More)
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Highly Cited
2001
Highly Cited
2001
Doublecortin expression in the adult rat telencephalon.
Doublecortin (DCX) is a protein required for normal neuronal migration in the developing cerebral cortex, where it is widely… (More)
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Highly Cited
1999
Highly Cited
1999
Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating Neurons
Doublecortin (DCX) is required for normal migration of neurons into the cerebral cortex, since mutations in the human gene cause… (More)
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Highly Cited
1999
Highly Cited
1999
Doublecortin Is a Developmentally Regulated, Microtubule-Associated Protein Expressed in Migrating and Differentiating Neurons
Recently, we and others reported that the doublecortin gene is responsible for X-linked lissencephaly and subcortical laminar… (More)
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Highly Cited
1999
Highly Cited
1999
Doublecortin, a stabilizer of microtubules.
X-linked lissencephaly is a severe brain malformation affecting males. Recently it has been demonstrated that the doublecortin… (More)
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