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Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
- C. Lucchinetti, W. Brück, J. Parisi, B. Scheithauer, Moses Rodriguez, H. Lassmann
- Medicine, BiologyAnnals of neurology
- 1 June 2000
At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms.
Cortical demyelination and diffuse white matter injury in multiple sclerosis.
- A. Kutzelnigg, C. Lucchinetti, H. Lassmann
- Psychology, MedicineBrain : a journal of neurology
- 1 November 2005
Global brain pathology in multiple sclerosis is analysed, focusing on the normal-appearing white matter (NAWM) and the cortex, to suggest that multiple sclerosis starts as a focal inflammatory disease of the CNS, which gives rise to circumscribed demyelinated plaques in the white matter.
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.
The ability of dimethylfumarate to activate nuclear factor (erythroid-derived 2)-related factor 2 may offer a novel cytoprotective modality that further augments the natural antioxidant responses in multiple sclerosis tissue and is not yet targeted by other multiple sclerosis therapies.
The Immunopathology of Multiple Sclerosis: An Overview
Recent evidence is described that the spectrum of MS pathology is much broader, including demyelination in the cortex and deep gray matter nuclei, as well as diffuse injury of the normal‐appearing white matter.
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
Using a panel of bone marrow chimeric and adoptive transfer experiments, it is found that circulating Ly-6ChiCCR2+ monocytes were preferentially recruited to the lesioned brain and differentiated into microglia.
Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis
Although lesion size >5 cm was associated with a slightly higher EDSS at last follow-up, long-term prognosis in patients with disease duration >10 years was better compared with a population-based multiple sclerosis cohort matched for disease duration (EDSS 3.5; P < 0.001).
DNA methylation-based classification of central nervous system tumours
This work presents a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and shows that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods.
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
In vivo imaging and pharmacological experiments show that macrophage-derived reactive oxygen and nitrogen species (ROS and RNS) can trigger mitochondrial pathology and initiate FAD, and suggest that inflammatory axon damage might be spontaneously reversible and thus a potential target for therapy.
Inflammatory cortical demyelination in early multiple sclerosis.
- C. Lucchinetti, B. Popescu, R. Ransohoff
- Medicine, PsychologyThe New England journal of medicine
- 8 December 2011
In this cohort of patients with early-stage multiple sclerosis, cortical demyelinating lesions were frequent, inflammatory, and strongly associated with meningeal inflammation.
Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time.
- T. Kuhlmann, Gueanelle Lingfeld, A. Bitsch, J. Schuchardt, W. Brück
- BiologyBrain : a journal of neurology
- 1 October 2002
The results indicate that a putative axon-protective treatment should start as early as possible and include strategies preventing T cell/macrophage-mediated axon destruction and leading to remyelination of axons.