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Intrinsic optical signals in rat neocortical slices measured with near- infrared dark-field microscopy reveal changes in extracellular space
  • K. Holthoff, O. Witte
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 15 April 1996
TLDR
Activity- dependent IOSs in rat neocortical slices measured by near-infrared video microscopy reveal changes in ECS, and the pharmacological and ion substitutional experiments make it likely that activity-induced I OSs are attributable to cell swelling via a net KCI uptake and a concomitant water influx. Expand
Anticoagulant reversal, blood pressure levels, and anticoagulant resumption in patients with anticoagulation-related intracerebral hemorrhage.
TLDR
Among patients with OAC-associated ICH, reversal of anticoagulation reversal and blood pressure (BP) with hematoma enlargement and resumption of OAC therapy was associated with lower risk of ischemic events, and these findings require replication and assessment in prospective studies. Expand
Neuronal Hyperexcitability and Reduction of GABAA-Receptor Expression in the Surround of Cerebral Photothrombosis
TLDR
It is concluded that cortical infarction due to photothrombosis leads to a long-lasting and widespread reduction of GABAA-receptor expression in the surround of the lesion, which is associated with an increased neuronal excitability. Expand
Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging
TLDR
The study clearly demonstrated that changes in GABA(A) receptor distribution not only occur in the early postnatal cortex and hippocampal formation but also during later periods in the adolescent and aging brain. Expand
Interaction of finger representation in the human first somatosensory cortex: a neuromagnetic study
TLDR
There is an overlap of finger representations in human SI which differs between anatomically adjacent and non-adjacent digit pairs, indicating that there is an overlaps in primary somatosensory cortex. Expand
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
TLDR
Evidence of ALS being a complex genetic trait with a polygenic architecture is established and the SNP-based heritability is estimated at 8.5%, with a distinct and important role for low-frequency variants (frequency 1–10%). Expand
Behavioral correlates of negative BOLD signal changes in the primary somatosensory cortex
TLDR
The negative BOLD signal changes in the area of the index finger highly correlated with an increase in current perception thresholds of the contralateral, unstimulated finger, thus supporting the notion that the ipsilateral negative Bold response reflects a functionally effective inhibition in the somatosensory system. Expand
Perception of phrase structure in music
TLDR
It is suggested that the CPS may not reflect the detection of the phrase boundary as such, but those memory and attention related processes that are necessary to guide the attention focus from one phrase to the next, thereby closing the former and opening up the next phrase. Expand
Functional Differentiation of Multiple Perilesional Zones after Focal Cerebral Ischemia
TLDR
A broad differentiation of separate topographic perilesional areas according to their functional state and sequelae allows segregation into several signaling cascades, and may help to understand the functional consequences and adaptive processes after focal brain ischemia. Expand
GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo.
TLDR
It is reported that at postnatal days (P) 3-4, GABA depolarizes the majority of immature neurons in the occipital cortex of anaesthetized mice and does not efficiently activate voltage-gated Ca(2+) channels and fails to induce action potential firing. Expand
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