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Neprilysin

Known as: CD10, Common Acute Lymphoblastic Leukemia Antigens, common acute lymphoblastic leukemia antigen (CALLA) 
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It… 
National Institutes of Health

Related topics

Related topics

16 relations
CALLA Positive Lymphoblastic LeukemiaCD10 Ag:PrThr:Pt:Tiss:Ord:Immune stainIn BloodMME gene

Narrower (2)

Human NeprilysinKB220Z

Broader (2)

MetalloendopeptidasesMetalloproteases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin
Abstract.The accumulation of aggregates of amyloidogenic peptides is associated with numerous human diseases. One well studied… 
Highly Cited
2004
Highly Cited
2004
Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain
A local increase in amyloid-β peptide (Aβ) is closely associated with synaptic dysfunction in the brain in Alzheimer's disease… 
Review
2002
Review
2002
β‐Amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?
The steady‐state level of amyloid β‐peptide (Aβ) represents a balance between its biosynthesis from the amyloid precursor protein… 
Review
1998
Review
1998
Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems
Abstract: The interaction between components of the nervous system and multiple target cells in the cutaneous immune system has… 
Highly Cited
1990
Highly Cited
1990
Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.
Pharmacologic, biochemical, and genetic analyses have demonstrated the existence of multiple alpha 2-adrenergic receptor (alpha… 
Highly Cited
1987
Highly Cited
1987
The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.
alpha-Human atrial natriuretic peptide, a 28-amino-acid-residue peptide, was rapidly hydrolysed by pig kidney microvillar… 
Highly Cited
1984
Highly Cited
1984
The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11.
Endopeptidase-24.11 (EC 3.4.24.11), purified to homogeneity from pig kidney, was shown to hydrolyse a wide range of neuropeptides… 
Highly Cited
1983
Highly Cited
1983
Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
The hydrolysis of [Leu]enkephalin and substance P by purified pig kidney endopeptidase (EC 3.4.24.11) and synaptic membranes… 
Highly Cited
1983
Highly Cited
1983
Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides.
After extracting converting enzyme from a membrane fraction of homogenized human kidney, "enkephalinase" activity was solubilized… 
Highly Cited
1980
Highly Cited
1980
The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice
There is both theoretical and therapeutic interest in establishing whether the signals conveyed by the enkephalins are turned off… 
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