G. Stefano

Publications550
h-index70
Citations17,802
Highly Influential Citations353
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The neurobiology of pleasure, reward processes, addiction and their health implications.
TLDR
The neurobiological factors underlying reward processes and pleasure phenomena are examined, and more research is needed to better understand the nature, neurobiology and maybe dangerous aspects of pleasure. Expand
Rapid stress reduction and anxiolysis among distressed women as a consequence of a three-month intensive yoga program.
TLDR
Women suffering from mental distress participating in a 3-month Iyengar yoga class show significant improvements on measures of stress and psychological outcomes. Expand
The Neurobiology of Love.
TLDR
Love, pleasure, and lust have a stress-reducing and health-promoting potential, since they carry the ability to heal or facilitate beneficial motivation and behavior and ensure the survival of individuals and their species. Expand
The neurobiology of stress management.
TLDR
There seems to exist a common neurobiological mechanism that involves dopamine, morphine and other endogenous signalling molecules, e.g., other opioid receptor agonists, endocannabinoids, oxytocin or serotonin, many of which act via NO release, and this share seems to be of critical importance for the self-regulation and management of stress: stress management is an endogenous potential. Expand
Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide
TLDR
The clinical convergence of advanced ageing in the presence of a chronic, pre-morbid vascular risk factor can, in time, contribute to an endotheliopathy involving basal NO deficit, to the degree where regional metabolic dysfunction leads to cognitive meltdown and to progressive neurodegeneration characteristic of Alzheimer's disease. Expand
Cannabinoid Receptors Are Coupled to Nitric Oxide Release in Invertebrate Immunocytes, Microglia, and Human Monocytes*
TLDR
The present study demonstrates that stereoselective binding sites for anandamide, a naturally occurring cannabinoid substance, can be found in invertebrate immunocytes and microglia and indicates that this signaling system has been conserved for more than 500 million years. Expand
The therapeutic use of the relaxation response in stress-related diseases.
TLDR
Investigation of the possible connection between the relaxation response (RR) and stress-related diseases found common underlying molecular mechanisms and autoregulatory pathways were examined, and RR techniques, regularly part of professional stress management or mind/body medical settings, represent an important tool to be added to therapeutic strategies dealing with stress- related diseases. Expand
Molecular Identification and Functional Expression of μ3, a Novel Alternatively Spliced Variant of the Human μ Opiate Receptor Gene1
TLDR
Data suggest that this new μ opiate receptor cDNA encodes the μ3 opiate receptors, since it exhibits biochemical characteristics known to be unique to this receptor (opiate alkaloid selective and opioid peptide insensitive). Expand
The role of stress in neurodegenerative diseases and mental disorders.
TLDR
Stress plays a major role in various (patho)physiological processes associated with neurodegenerative diseases and mental disorders and may even improve performance/biological functions and be beneficial in certain cases. Expand
Immune processes in the pathogenesis of Parkinson's disease - a potential role for microglia and nitric oxide.
TLDR
Inflammation initiated by neuronal damage in the striatum and the substantia nigra in PD may aggravate the course of the disease, and treatment with anti-inflammatory drugs may act to slow progression of PD. Expand
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