Negative Selection

The separation of specific cells or cell populations from a heterogeneous mixture. Specifically it refers to the selective removal of a population of… (More)
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
During development, discrete cell fates often result from variation in the intensity of a particular signal. The mechanisms… (More)
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Review
2000
Review
2000
Self-tolerance induction is largely a reflection of negative selection (deletion) of autoreactive T cells in the thymus. Evidence… (More)
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Highly Cited
1998
Highly Cited
1998
Clonal selection of T lymphocytes is essential for establishing self/non-self discrimination of immune recognition. It is known… (More)
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Highly Cited
1997
Highly Cited
1997
The T cell repertoire is shaped by positive and negative selection of thymocytes that express low levels of T cell receptor (TCR… (More)
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Highly Cited
1996
Highly Cited
1996
During T cell development, interaction of the T cell receptor (TCR) with cognate ligands in the thymus may result in either… (More)
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Highly Cited
1995
Highly Cited
1995
B lymphocytes recognize antigen through membrane-bound antigen-receptors, membrane IgM and IgD (mIgM and mIgD). Binding to… (More)
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Highly Cited
1995
Highly Cited
1995
Small molecular weight GTP binding proteins of the ras family have been implicated in signal transduction from the T cell antigen… (More)
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Highly Cited
1995
Highly Cited
1995
The transcription factor Nur77, an orphan member of the nuclear hormone receptor superfamily, is highly expressed during T cell… (More)
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Highly Cited
1994
Highly Cited
1994
BECAUSE of positive and negative selection to molecules of the major histocompatibility complex (MHC)1, only a small propor-tion… (More)
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Highly Cited
1992
Highly Cited
1992
Expression of the bacterial gene for cytosine deaminase (CD; EC 3.5.4.1) in mammalian cells was evaluated as a negative selection… (More)
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