Skip to search formSkip to main contentSkip to account menu

Negative Selection

The separation of specific cells or cell populations from a heterogeneous mixture. Specifically it refers to the selective removal of a population of… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Receptor Editing in Positive and Negative Selection of B Lymphopoiesis1
In B lymphopoiesis, Ag receptor expression and signaling are critical to determine developmental progression, survival, and… 
Highly Cited
1999
Highly Cited
1999
CD30 overexpression enhances negative selection in the thymus and mediates programmed cell death via a Bcl-2-sensitive pathway.
The biological function of CD30 in the thymus has been only partially elucidated, although recent data indicate that it may be… 
Highly Cited
1999
Highly Cited
1999
Cutting edge: negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells.
We quantitated the number of peptide-class II MHC complexes required to affect the deletion or activation of 3A9 TCR transgenic… 
Highly Cited
1998
Highly Cited
1998
Impaired negative selection in CD28-deficient mice.
T cell antigen receptors (TCR) expressed on developing T cells can react with self-peptides presented by proteins encoded by the… 
Highly Cited
1994
Highly Cited
1994
Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection
Successful interaction of the T cell receptor (TCR) with major histocompatibility complex (MHC) molecules during thymic selection… 
Highly Cited
1994
Highly Cited
1994
Thymic CD45 tyrosine phosphatase regulates apoptosis and MHC-restricted negative selection.
The acquisition of immunologic self-tolerance is governed, in part, by selection mechanisms that occur during intrathymic T cell… 
Highly Cited
1993
Highly Cited
1993
CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny
During thymic development, immature thymocytes expressing major histocompatibility complex (MHC) class I‐restricted T cell… 
Highly Cited
1992
Highly Cited
1992
Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells
The interaction of the T cell surface glycoprotein CD8 with major histocompatibility complex (MHC) class I molecules on target… 
Highly Cited
1991
Highly Cited
1991
Co-engagement of CD8 with the T cell receptor is required for negative selection
ALTHOUGH it is established that the CDS and CD4 co-receptors are involved in T-lymphocyte recognition and activation in the… 
Highly Cited
1989
Highly Cited
1989
Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus
The role of thymic MHC class II-bearing cells in the selection of the TCR repertoire has been investigated in allogeneic… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)