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Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
TLDR
T-cell tolerance in transgenic mice expressing a T-cell receptor with double specificities for lymphocytic choriomeningitis virus (LCMV)-H-2Db and for the mixed-lymphocyte stimulatory (Mlsa) antigen is studied. Expand
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
TLDR
Perforin-deficient mice have been generated by homologous recombination to determine whether the effects of CDS+ cytolytic T cells and natural killer cells are mediated by pore formation involving perform, and perforin is therefore a key effector molecule for T-cell- and natural Killer- cell-mediated cy tolysis. Expand
Virus‐specific major MHC class II‐restricted TCR‐transgenic mice: effects on humoral and cellular immune responses after viral infection
TLDR
It is demonstrated that functional LCMV‐specific CD4+ T cells – even if activated and present at extremely high frequencies – cannot directly mediate protective immunity against LCV, and further support the need for different immune effector functions for Protective immunity against different viral infections. Expand
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria.
TLDR
The IgA against intestinal commensal bacterial antigens was analyzed; it was not simply "natural antibody" but was specifically induced and responded to antigenic changes within an established gut flora. Expand
Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice
TLDR
This model indicates that self-reactive cytotoxic T cells may remain functionally unresponsive, owing to a lack of appropriate T cell activation, in so-called "T cell-mediated autoimmune diseases". Expand
Control of early viral and bacterial distribution and disease by natural antibodies.
TLDR
In antibody-free mice infected with various viruses or with Listeria monocytogenes, viral or bacterial Titers in peripheral organs were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary lymphoid organs were very low. Expand
Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo
TLDR
It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope. Expand
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.
TLDR
The perforin- and Fas-based mechanisms may account for all T cell-mediated cytotoxicity in short-term in vitro assays, and no third mechanism was detected. Expand
Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.
TLDR
Evidence for a role of Fas-dependent cytotoxicity as a T cell effector mechanism in vivo is lacking, and current data suggest that the main function of Fas may be in regulation of the immune response and apparently less at the level of an effector mechanisms in host defense. Expand
Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.
TLDR
It is proposed that parasite-induced polyclonal antibodies play a dual role, whereby the parasite is allowed to establish chronicity, while parasite load and spread are limited, likely reflecting the long coevolution of helminth parasites with their hosts. Expand
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