Blood monocytes consist of two principal subsets with distinct migratory properties.
- F. Geissmann, Steffen Jung, D. Littman
- BiologyImmunity
- 1 July 2003
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
- I. Ivanov, B. McKenzie, D. Littman
- BiologyCell
- 2006
It is shown that the orphan nuclear receptor RORgammat is the key transcription factor that orchestrates the differentiation of this effector cell lineage of proinflammatory T helper cells and its potential as a therapeutic target in inflammatory diseases is highlighted.
ATP mediates rapid microglial response to local brain injury in vivo
- D. Davalos, J. Grutzendler, W. Gan
- BiologyNature Neuroscience
- 1 June 2005
Extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglia response towards injury.
Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion
- Steffen Jung, J. Aliberti, D. Littman
- BiologyMolecular and Cellular Biology
- 1 June 2000
Defying anticipated FKN functions, absence of CX3CR1 interferes neither with monocyte extravasation in a peritonitis model nor with DC migration and differentiation in response to microbial antigens or contact sensitizers.
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
- I. Ivanov, K. Atarashi, D. Littman
- Biology, MedicineCell
- 30 October 2009
Identification of a major co-receptor for primary isolates of HIV-1
The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, Mip-1α and MIP-1β.
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells
- T. Geijtenbeek, D. Kwon, Y. Kooyk
- BiologyCell
- 3 March 2000
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
- J. Burns, B. Summers, T. Schall
- Biology, ChemistryJournal of Experimental Medicine
- 4 September 2006
A specific, high affinity small molecule antagonist to CXCR7 impedes in vivo tumor growth in animal models, validating this new receptor as a target for development of novel cancer therapeutics.
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
- Steffen Jung, D. Unutmaz, R. Lang
- BiologyImmunity
- 1 August 2002
Control of microglial neurotoxicity by the fractalkine receptor
- A. Cardona, E. Pioro, R. Ransohoff
- Biology, ChemistryNature Neuroscience
- 1 July 2006
Augmenting CX3CR1 signaling may protect against microglial neurotoxicity, whereas CNS penetration by pharmaceutical CX2CR1 antagonists could increase neuronal vulnerability.
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